musculoskeletal system disease: A disease involving the musculoskeletal system. [database_cross_reference: MONDO:DesignPattern]
Other disorders of the musculoskeletal system and connective tissue
DOID EFO Endpoint Browser PheWeb
M13_MUSCULOSKELEOTH
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
3815 |
4. Check minimum number of eventsNone |
3815 |
5. Include endpoints |
5248 |
6. Filter based on genotype QC (FinnGen only) |
5042 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other disorders of the musculoskeletal system and connective tissue
based on the number of shared cases.
Similar with more cases:
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 42034 | 22263 | 19467 |
| Only index persons | 37295 | 20148 | 17147 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.59 | 0.64 | 0.54 |
| Only index persons | 0.70 | 0.74 | 0.65 |
| Median age at first event (years) | |||
| Whole population | 50.65 | 53.46 | 47.40 |
| Only index persons | 49.27 | 52.21 | 45.81 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 5042 | 2843 | 2199 |
| Unadjusted period prevalence (%) | 1.11 | 1.12 | 1.10 |
| Median age at first event (years) | 51.56 | 50.38 | 53.09 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_MUSCULOSKELEOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_MUSCULOSKELEOTH | 1.409 [1.26, 1.58] | < 0.001 |
| Birth year | 0.997 [0.99, 1.0] | 0.409 |
During the follow-up period (1.1.1998 — 31.12.2019), 2181 out of 11712 females with M13_MUSCULOSKELEOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_MUSCULOSKELEOTH | 1.31 [1.17, 1.47] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 1812 out of 10577 males with M13_MUSCULOSKELEOTH died.
Mortality risk
Mortality risk for people of age
years, who have M13_MUSCULOSKELEOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.159% | 0.27% |
| 5 | 0.828% | 1.402% |
| 10 | 2.178% | 3.571% |
| 15 | 4.184% | 6.955% |
| 20 | 7.422% | 11.411% |
Relationships between endpoints
↥Index endpoint: M13_MUSCULOSKELEOTH – Other disorders of the musculoskeletal system and connective tissue
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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