musculoskeletal system disease: A disease involving the musculoskeletal system. [database_cross_reference: MONDO:DesignPattern]
Postprocedural musculoskeletal disorders, not elsewhere classified
DOID EFO Endpoint Browser PheWeb
M13_POSTOPMUSCULOSKE
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2219 |
4. Check minimum number of eventsNone |
2219 |
5. Include endpointsNone |
2219 |
6. Filter based on genotype QC (FinnGen only) |
2165 |
Control definitions (FinnGen only)
Control exclude
M13_MUSCULOSKELEOTH
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M95-M99
Name in latin
Morbositates musculosceletales post interventiones non alibi classificati
Similar endpoints
↥List of similar endpoints to
Postprocedural musculoskeletal disorders, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Other disorders of the musculoskeletal system and connective tissue
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 16616 | 9529 | 7003 |
| Only index persons | 15255 | 9021 | 6234 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.24 | 0.27 | 0.20 |
| Only index persons | 0.29 | 0.33 | 0.24 |
| Median age at first event (years) | |||
| Whole population | 60.08 | 63.04 | 56.06 |
| Only index persons | 59.85 | 62.69 | 55.74 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2165 | 1269 | 896 |
| Unadjusted period prevalence (%) | 0.48 | 0.50 | 0.45 |
| Median age at first event (years) | 57.79 | 57.44 | 58.28 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_POSTOPMUSCULOSKE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_POSTOPMUSCULOSKE | 1.476 [1.29, 1.69] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.329 |
During the follow-up period (1.1.1998 — 31.12.2019), 1446 out of 6530 females with M13_POSTOPMUSCULOSKE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_POSTOPMUSCULOSKE | 1.321 [1.13, 1.54] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.019 |
During the follow-up period (1.1.1998 — 31.12.2019), 891 out of 4176 males with M13_POSTOPMUSCULOSKE died.
Mortality risk
Mortality risk for people of age
years, who have M13_POSTOPMUSCULOSKE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.166% | 0.264% |
| 5 | 0.762% | 1.623% |
| 10 | 2.021% | 4.192% |
| 15 | 4.241% | 7.917% |
| 20 | 7.035% | 13.441% |
Relationships between endpoints
↥Index endpoint: M13_POSTOPMUSCULOSKE – Postprocedural musculoskeletal disorders, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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