musculoskeletal system disease: A disease involving the musculoskeletal system. [database_cross_reference: MONDO:DesignPattern]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1548 |
4. Check minimum number of eventsNone |
1548 |
5. Include endpointsNone |
1548 |
6. Filter based on genotype QC (FinnGen only) |
1484 |
Control definitions (FinnGen only)
Control exclude
M13_MUSCULOSKELEOTH
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M95-M99
Name in latin
Laesio biomechanica non alibi classificata
Similar endpoints
↥List of similar endpoints to
Biomechanical lesions, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Other disorders of the musculoskeletal system and connective tissue
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 11514 | 6360 | 5079 |
| Only index persons | 9818 | 5551 | 4267 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.18 | 0.14 |
| Only index persons | 0.19 | 0.20 | 0.16 |
| Median age at first event (years) | |||
| Whole population | 53.30 | 53.79 | 52.53 |
| Only index persons | 50.54 | 51.17 | 49.72 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1484 | 868 | 616 |
| Unadjusted period prevalence (%) | 0.33 | 0.34 | 0.31 |
| Median age at first event (years) | 52.75 | 49.68 | 57.06 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_BIOMECHLESIO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_BIOMECHLESIO | 1.163 [1.04, 1.3] | 0.01 |
| Birth year | 0.991 [0.98, 1.0] | 0.05 |
During the follow-up period (1.1.1998 — 31.12.2019), 583 out of 3050 females with M13_BIOMECHLESIO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_BIOMECHLESIO | 1.207 [1.07, 1.36] | 0.002 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 596 out of 2252 males with M13_BIOMECHLESIO died.
Mortality risk
Mortality risk for people of age
years, who have M13_BIOMECHLESIO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.088% | 0.179% |
| 5 | 0.625% | 1.357% |
| 10 | 1.566% | 3.251% |
| 15 | 3.048% | 6.271% |
| 20 | 5.052% | 10.661% |
Relationships between endpoints
↥Index endpoint: M13_BIOMECHLESIO – Biomechanical lesions, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data