No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
25192 |
4. Check minimum number of eventsNone |
25192 |
5. Include endpointsNone |
25192 |
6. Filter based on genotype QC (FinnGen only) |
24395 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF3
Similar endpoints
↥List of similar endpoints to
Coxarthrosis, primary
based on the number of shared cases.
Similar with more cases:
- Coxarthrosis
- Coxarthrosis [arthrosis of hip](FG)
- Arthrosis
- Finngen Rheumatological endpoints
- Artrosis, including avohilmo
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 193957 | 110347 | 82845 |
| Only index persons | 179933 | 103468 | 76465 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.79 | 3.16 | 2.31 |
| Only index persons | 3.43 | 3.80 | 2.92 |
| Median age at first event (years) | |||
| Whole population | 68.56 | 69.91 | 66.72 |
| Only index persons | 67.96 | 69.34 | 66.10 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 24395 | 13163 | 11232 |
| Unadjusted period prevalence (%) | 5.39 | 5.17 | 5.64 |
| Median age at first event (years) | 66.08 | 65.83 | 66.37 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_ARTHTROSIS_COX_PRIM_ICD10 and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ARTHTROSIS_COX_PRIM_ICD10 | 0.925 [0.86, 0.99] | 0.03 |
| Birth year | 0.993 [0.99, 1.0] | 0.085 |
During the follow-up period (1.1.1998 — 31.12.2019), 24730 out of 94461 females with M13_ARTHTROSIS_COX_PRIM_ICD10 died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ARTHTROSIS_COX_PRIM_ICD10 | 0.911 [0.84, 0.98] | 0.018 |
| Birth year | 0.988 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 19709 out of 70937 males with M13_ARTHTROSIS_COX_PRIM_ICD10 died.
Mortality risk
Mortality risk for people of age
years, who have M13_ARTHTROSIS_COX_PRIM_ICD10.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.087% | 0.167% |
| 5 | 0.513% | 1.039% |
| 10 | 1.152% | 2.525% |
| 15 | 2.191% | 4.797% |
| 20 | 3.94% | 8.337% |
Relationships between endpoints
↥Index endpoint: M13_ARTHTROSIS_COX_PRIM_ICD10 – Coxarthrosis, primary
GWS hits: 45
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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