No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
10724 |
4. Check minimum number of eventsNone |
10724 |
5. Include endpointsNone |
10724 |
6. Filter based on genotype QC (FinnGen only) |
10408 |
Control definitions (FinnGen only)
Control exclude
COX_ARTHROSIS
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M16
Name in latin
Coxarthrosis primaria bilateralis
Similar endpoints
↥List of similar endpoints to
Primary coxarthrosis, bilateral
based on the number of shared cases.
Similar with more cases:
- Coxarthrosis, primary
- Coxarthrosis [arthrosis of hip](FG)
- Coxarthrosis
- Arthrosis
- Finngen Rheumatological endpoints
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 83803 | 47388 | 36086 |
| Only index persons | 77467 | 44252 | 33215 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.20 | 1.36 | 1.01 |
| Only index persons | 1.47 | 1.63 | 1.27 |
| Median age at first event (years) | |||
| Whole population | 69.55 | 71.00 | 67.61 |
| Only index persons | 68.95 | 70.48 | 66.91 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 10408 | 5546 | 4862 |
| Unadjusted period prevalence (%) | 2.30 | 2.18 | 2.44 |
| Median age at first event (years) | 66.75 | 66.78 | 66.71 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint PRIM_COXARTHROSIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| PRIM_COXARTHROSIS | 0.953 [0.89, 1.02] | 0.189 |
| Birth year | 0.989 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 11796 out of 40904 females with PRIM_COXARTHROSIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| PRIM_COXARTHROSIS | 0.951 [0.88, 1.03] | 0.215 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 9268 out of 31203 males with PRIM_COXARTHROSIS died.
Mortality risk
Mortality risk for people of age
years, who have PRIM_COXARTHROSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.063% | 0.196% |
| 5 | 0.422% | 1.089% |
| 10 | 1.132% | 2.817% |
| 15 | 2.175% | 5.379% |
| 20 | 3.78% | 8.962% |
Relationships between endpoints
↥Index endpoint: PRIM_COXARTHROSIS – Primary coxarthrosis, bilateral
GWS hits: 19
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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