No definition available.
Coxarthrosis, primary, with hip surgery
EFO MESH Endpoint Browser PheWeb
M13_ARTHTROSIS_COX_PRIM_HIPSURG
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
25192 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
18652 |
4. Check minimum number of eventsNone |
18652 |
5. Include endpointsNone |
18652 |
6. Filter based on genotype QC (FinnGen only) |
18094 |
Control definitions (FinnGen only)
Control conditions
not M13_ARTHTROSIS_COX_PRIM_ICD10
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF3
Similar endpoints
↥List of similar endpoints to
Coxarthrosis, primary, with hip surgery
based on the number of shared cases.
Similar with more cases:
- Coxarthrosis, primary
- Coxarthrosis
- Coxarthrosis [arthrosis of hip](FG)
- Arthrosis
- Finngen Rheumatological endpoints
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 142510 | 80843 | 61201 |
| Only index persons | 134398 | 76934 | 57464 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.05 | 2.32 | 1.71 |
| Only index persons | 2.56 | 2.83 | 2.19 |
| Median age at first event (years) | |||
| Whole population | 68.93 | 70.19 | 67.23 |
| Only index persons | 68.53 | 69.83 | 66.79 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 18094 | 9698 | 8396 |
| Unadjusted period prevalence (%) | 4.00 | 3.81 | 4.22 |
| Median age at first event (years) | 66.80 | 66.77 | 66.84 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_ARTHTROSIS_COX_PRIM_HIPSURG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ARTHTROSIS_COX_PRIM_HIPSURG | 0.817 [0.76, 0.88] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.489 |
During the follow-up period (1.1.1998 — 31.12.2019), 16936 out of 69691 females with M13_ARTHTROSIS_COX_PRIM_HIPSURG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ARTHTROSIS_COX_PRIM_HIPSURG | 0.845 [0.78, 0.91] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 13874 out of 53049 males with M13_ARTHTROSIS_COX_PRIM_HIPSURG died.
Mortality risk
Mortality risk for people of age
years, who have M13_ARTHTROSIS_COX_PRIM_HIPSURG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.088% | 0.137% |
| 5 | 0.391% | 0.908% |
| 10 | 1.046% | 2.349% |
| 15 | 2.04% | 4.629% |
| 20 | 3.971% | 7.655% |
Relationships between endpoints
↥Index endpoint: M13_ARTHTROSIS_COX_PRIM_HIPSURG – Coxarthrosis, primary, with hip surgery
GWS hits: 49
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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