Other disorders of skin and subcutaneous tissue related to radiation

L12_SKINRADIOTH

photosensitivity disease: Photosensitivity refers to various symptoms, diseases and conditions caused or aggravated by exposure to sunlight.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L59
  • Cause of death: ICD-10 L59

2 out of 7 registries used, show all original rules.

56

4. Check minimum number of events

None

56

5. Include endpoints

56

6. Filter based on genotype QC (FinnGen only)

54

Control definitions (FinnGen only)

Control exclude L12_RADIATIONRELATEDSKIN

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L55-L59
Name in latin Aliae morbositates cutis et telae subcutaneae e radiatione

Similar endpoints

List of similar endpoints to Other disorders of skin and subcutaneous tissue related to radiation based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 422 251 168
Only index persons 350 224 126
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.00
Only index persons 0.01 0.01 0.00
Median age at first event (years)
Whole population 56.02 58.38 52.65
Only index persons 54.89 57.35 50.54

-FinnGen-

Key figures

All Female Male
Number of individuals 54 42 12
Unadjusted period prevalence (%) 0.01 0.02 0.01
Median age at first event (years) 55.02 55.70 52.65

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint L12_SKINRADIOTH and mortality.

Females

Parameter HR [95% CI] p-value
L12_SKINRADIOTH 1.687 [1.14, 2.49] 0.009
Birth year 0.999 [0.99, 1.01] 0.785

During the follow-up period (1.1.1998 — 31.12.2019), 75 out of 227 females with L12_SKINRADIOTH died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_SKINRADIOTH.

N-year risk Females Males
1 0.147% No data
5 1.144% No data
10 2.755% No data
15 5.425% No data
20 9.691% No data

Relationships between endpoints

Index endpoint: L12_SKINRADIOTH – Other disorders of skin and subcutaneous tissue related to radiation

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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