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Other and unspecified papulosquamous disorders

MESH Endpoint Browser PheWeb

L12_PAPULOSQUONAS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L44.8, L44.9
  • Hospital discharge: ICD-9 — 697[8-9]|6970
  • Hospital discharge: ICD-8 — 69799|696[5-9]
  • Cause of death: ICD-10 — L44.8, L44.9
  • Cause of death: ICD-9 — 697[8-9]|6970
  • Cause of death: ICD-8 — 69799|696[5-9]

2 out of 7 registries used, show all original rules.

196

4. Check minimum number of events

None

196

5. Include endpoints

None

196

6. Filter based on genotype QC (FinnGen only)

184

Control definitions (FinnGen only)

Control exclude L12_PAPULOSQUAMOUS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2302 1336 944
Only index persons 1746 1046 700
Unadjusted period prevalence (%)
Whole population 0.03 0.04 0.03
Only index persons 0.03 0.04 0.03
Median age at first event (years)
Whole population 44.89 48.49 39.61
Only index persons 39.20 43.78 32.35

-FinnGen-

Key figures

All Female Male
Number of individuals 184 103 81
Unadjusted period prevalence (%) 0.04 0.04 0.04
Median age at first event (years) 45.22 43.93 46.86

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint L12_PAPULOSQUONAS and mortality.

Females

Parameter HR [95% CI] p-value
L12_PAPULOSQUONAS 1.667 [1.17, 2.38] 0.005
Birth year 0.992 [0.98, 1.0] 0.063

During the follow-up period (1.1.1998 — 31.12.2019), 87 out of 566 females with L12_PAPULOSQUONAS died.

Males

Parameter HR [95% CI] p-value
L12_PAPULOSQUONAS 1.932 [1.32, 2.84] < 0.001
Birth year 0.987 [0.98, 1.0] 0.008

During the follow-up period (1.1.1998 — 31.12.2019), 88 out of 428 males with L12_PAPULOSQUONAS died.

Mortality risk

Mortality risk for people of age

years, who have L12_PAPULOSQUONAS.

N-year risk Females Males
1 0.115% 0.391%
5 0.836% 2.163%
10 2.197% 5.375%
15 4.318% 10.143%
20 7.431% 16.83%

Relationships between endpoints

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Index endpoint: L12_PAPULOSQUONAS – Other and unspecified papulosquamous disorders

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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