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Other and unspecified acute skin changes due to ultraviolet radiation

DOID EFO Endpoint Browser PheWeb

L12_OTHACUSKINSUNNAS

phototoxic dermatitis: a form of allergic contact dermatitis in which the allergen must be activated by light to sensitize the allergic response, and to cause a rash or other systemic effects on subsequent exposure. The second and subsequent exposures produce photoallergic skin conditions which are often eczematous. In rare cases the victims die.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L56.8, L56.9
  • Hospital discharge: ICD-9 — 6927
  • Hospital discharge: ICD-8 — 6928
  • Hospital discharge: excluded ICD-9 — 6927F
  • Cause of death: ICD-10 — L56.8, L56.9
  • Cause of death: ICD-9 — 6927
  • Cause of death: ICD-8 — 6928
  • Cause of death: excluded ICD-9 — 6927F

2 out of 7 registries used, show all original rules.

871

4. Check minimum number of events

None

871

5. Include endpoints

None

871

6. Filter based on genotype QC (FinnGen only)

848

Control definitions (FinnGen only)

Control exclude L12_RADIATIONRELATEDSKIN

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 9789 4557 5076
Only index persons 6433 3241 3192
Unadjusted period prevalence (%)
Whole population 0.14 0.13 0.14
Only index persons 0.12 0.12 0.12
Median age at first event (years)
Whole population 44.43 47.31 41.57
Only index persons 35.57 39.46 31.63

-FinnGen-

Key figures

All Female Male
Number of individuals 848 367 481
Unadjusted period prevalence (%) 0.20 0.14 0.24
Median age at first event (years) 37.98 37.69 38.20

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint L12_OTHACUSKINSUNNAS and mortality.

Females

Parameter HR [95% CI] p-value
L12_OTHACUSKINSUNNAS 0.923 [0.74, 1.15] 0.471
Birth year 0.993 [0.98, 1.0] 0.128

During the follow-up period (1.1.1998 — 31.12.2019), 134 out of 829 females with L12_OTHACUSKINSUNNAS died.

Males

Parameter HR [95% CI] p-value
L12_OTHACUSKINSUNNAS 1.121 [0.91, 1.38] 0.29
Birth year 0.983 [0.97, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 194 out of 643 males with L12_OTHACUSKINSUNNAS died.

Mortality risk

Mortality risk for people of age

years, who have L12_OTHACUSKINSUNNAS.

N-year risk Females Males
1 0.089% 0.185%
5 0.486% 1.079%
10 1.204% 2.838%
15 2.335% 5.413%
20 4.209% 9.097%

Relationships between endpoints

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Index endpoint: L12_OTHACUSKINSUNNAS – Other and unspecified acute skin changes due to ultraviolet radiation

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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