phototoxic dermatitis: a form of allergic contact dermatitis in which the allergen must be activated by light to sensitize the allergic response, and to cause a rash or other systemic effects on subsequent exposure. The second and subsequent exposures produce photoallergic skin conditions which are often eczematous. In rare cases the victims die.
Other acute skin changes due to ultraviolet radiation
DOID EFO Endpoint Browser PheWeb
L12_OTHACUSKINSUN
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
578 |
4. Check minimum number of eventsNone |
578 |
5. Include endpoints |
1208 |
6. Filter based on genotype QC (FinnGen only) |
1175 |
Control definitions (FinnGen only)
Control exclude
L12_RADIATIONRELATEDSKIN
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L55-L59
Name in latin
Aliae commutationes acutae cutis e radiatione ultraviolacea
Similar endpoints
↥List of similar endpoints to
Other acute skin changes due to ultraviolet radiation
based on the number of shared cases.
Similar with more cases:
- Radiation-related disorders of the skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 12305 | 6288 | 5855 |
| Only index persons | 8709 | 4853 | 3856 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.17 | 0.18 | 0.16 |
| Only index persons | 0.16 | 0.18 | 0.15 |
| Median age at first event (years) | |||
| Whole population | 44.15 | 46.17 | 41.73 |
| Only index persons | 37.54 | 41.00 | 33.18 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1175 | 619 | 556 |
| Unadjusted period prevalence (%) | 0.26 | 0.24 | 0.28 |
| Median age at first event (years) | 40.78 | 40.76 | 40.81 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint L12_OTHACUSKINSUN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_OTHACUSKINSUN | 0.926 [0.79, 1.09] | 0.361 |
| Birth year | 0.998 [0.99, 1.01] | 0.614 |
During the follow-up period (1.1.1998 — 31.12.2019), 231 out of 2255 females with L12_OTHACUSKINSUN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_OTHACUSKINSUN | 1.147 [0.96, 1.37] | 0.129 |
| Birth year | 0.99 [0.98, 1.0] | 0.046 |
During the follow-up period (1.1.1998 — 31.12.2019), 282 out of 1251 males with L12_OTHACUSKINSUN died.
Mortality risk
Mortality risk for people of age
years, who have L12_OTHACUSKINSUN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.099% | 0.216% |
| 5 | 0.486% | 1.37% |
| 10 | 1.451% | 3.59% |
| 15 | 2.824% | 6.989% |
| 20 | 5.077% | 12.099% |
Relationships between endpoints
↥Index endpoint: L12_OTHACUSKINSUN – Other acute skin changes due to ultraviolet radiation
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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