localised scleroderma: Localized scleroderma is the skin localized form of scleroderma (see this term) characterized by fibrosis of the skin causing cutaneous plaques or strips.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
473 |
4. Check minimum number of eventsNone |
473 |
5. Include endpointsNone |
473 |
6. Filter based on genotype QC (FinnGen only) |
450 |
Control definitions (FinnGen only)
Control exclude
L12_OTHERSKINSUBCUTIS
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L94
Name in latin
Scleroderma circumscriptum
Similar endpoints
↥List of similar endpoints to
Localized scleroderma [morphea]
based on the number of shared cases.
Similar with more cases:
- Other localized connective tissue disorders
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3160 | 2461 | 682 |
| Only index persons | 2953 | 2322 | 631 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.07 | 0.02 |
| Only index persons | 0.07 | 0.09 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 52.33 | 54.73 | 43.53 |
| Only index persons | 51.81 | 54.19 | 43.06 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 450 | 372 | 78 |
| Unadjusted period prevalence (%) | 0.13 | 0.15 | 0.04 |
| Median age at first event (years) | 54.85 | 55.41 | 52.17 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint L12_LOCALSCLERODERMA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_LOCALSCLERODERMA | 1.057 [0.89, 1.26] | 0.536 |
| Birth year | 0.991 [0.98, 1.0] | 0.034 |
During the follow-up period (1.1.1998 — 31.12.2019), 207 out of 2016 females with L12_LOCALSCLERODERMA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_LOCALSCLERODERMA | 1.088 [0.8, 1.49] | 0.599 |
| Birth year | 0.989 [0.98, 1.0] | 0.018 |
During the follow-up period (1.1.1998 — 31.12.2019), 62 out of 560 males with L12_LOCALSCLERODERMA died.
Mortality risk
Mortality risk for people of age
years, who have L12_LOCALSCLERODERMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.082% | 0.212% |
| 5 | 0.556% | 1.342% |
| 10 | 1.324% | 3.33% |
| 15 | 2.594% | 6.147% |
| 20 | 4.421% | 10.464% |
Relationships between endpoints
↥Index endpoint: L12_LOCALSCLERODERMA – Localized scleroderma [morphea]
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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