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Dermatitis due to substances taken internally

EFO MESH Endpoint Browser PheWeb

L12_INTERNALSUBSTANCEDERM

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L27
  • Hospital discharge: ICD-9 — 693
  • Hospital discharge: excluded ICD-9 — L272
  • Cause of death: ICD-10 — L27
  • Cause of death: ICD-9 — 693
  • Cause of death: excluded ICD-9 — L272

2 out of 7 registries used, show all original rules.

3280

4. Check minimum number of events

None

3280

5. Include endpoints

None

3280

6. Filter based on genotype QC (FinnGen only)

3151

Control definitions (FinnGen only)

Control exclude L12_DERMATITISECZEMA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L20-L30
Name in latin Dermatitis e substantiis devoratis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 71494 33144 38224
Only index persons 51761 24618 27143
Unadjusted period prevalence (%)
Whole population 1.01 0.95 1.07
Only index persons 0.97 0.91 1.04
Median age at first event (years)
Whole population 2.09 2.57 1.46
Only index persons 2.60 3.81 1.49

-FinnGen-

Key figures

All Female Male
Number of individuals 3151 2021 1130
Unadjusted period prevalence (%) 0.71 0.79 0.57
Median age at first event (years) 32.32 34.20 28.95

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint L12_INTERNALSUBSTANCEDERM and mortality.

Females

Parameter HR [95% CI] p-value
L12_INTERNALSUBSTANCEDERM 1.819 [1.57, 2.11] < 0.001
Birth year 0.994 [0.99, 1.0] 0.166

During the follow-up period (1.1.1998 — 31.12.2019), 1622 out of 27428 females with L12_INTERNALSUBSTANCEDERM died.

Males

Parameter HR [95% CI] p-value
L12_INTERNALSUBSTANCEDERM 1.857 [1.53, 2.25] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 1133 out of 32403 males with L12_INTERNALSUBSTANCEDERM died.

Mortality risk

Mortality risk for people of age

years, who have L12_INTERNALSUBSTANCEDERM.

N-year risk Females Males
1 0.189% 0.283%
5 1.034% 1.946%
10 2.461% 4.837%
15 4.813% 9.447%
20 8.364% 15.4%

Relationships between endpoints

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Index endpoint: L12_INTERNALSUBSTANCEDERM – Dermatitis due to substances taken internally

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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