No definition available.
Localized skin eruption due to drugs and medicaments
LOCALIZED_SKIN_ERUPT_DRUGS_MEDICAM
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
347 |
4. Check minimum number of eventsNone |
347 |
5. Include endpointsNone |
347 |
6. Filter based on genotype QC (FinnGen only) |
330 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5
Similar endpoints
↥List of similar endpoints to
Localized skin eruption due to drugs and medicaments
based on the number of shared cases.
Similar with more cases:
- Dermatitis due to substances taken internally
- Dermatitis and eczema
- Diseases of the skin and subcutaneous tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2626 | 1498 | 1115 |
| Only index persons | 2347 | 1368 | 979 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.03 |
| Only index persons | 0.04 | 0.05 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 51.43 | 54.02 | 47.91 |
| Only index persons | 52.21 | 54.10 | 49.55 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 330 | 202 | 128 |
| Unadjusted period prevalence (%) | 0.07 | 0.08 | 0.06 |
| Median age at first event (years) | 55.43 | 53.26 | 58.87 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint LOCALIZED_SKIN_ERUPT_DRUGS_MEDICAM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| LOCALIZED_SKIN_ERUPT_DRUGS_MEDICAM | 1.557 [1.26, 1.93] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.626 |
During the follow-up period (1.1.1998 — 31.12.2019), 246 out of 1248 females with LOCALIZED_SKIN_ERUPT_DRUGS_MEDICAM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| LOCALIZED_SKIN_ERUPT_DRUGS_MEDICAM | 1.561 [1.26, 1.93] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.027 |
During the follow-up period (1.1.1998 — 31.12.2019), 181 out of 969 males with LOCALIZED_SKIN_ERUPT_DRUGS_MEDICAM died.
Mortality risk
Mortality risk for people of age
years, who have LOCALIZED_SKIN_ERUPT_DRUGS_MEDICAM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.143% | 0.415% |
| 5 | 1.089% | 2.227% |
| 10 | 2.717% | 5.267% |
| 15 | 4.883% | 9.734% |
| 20 | 8.541% | 15.853% |
Relationships between endpoints
↥Index endpoint: LOCALIZED_SKIN_ERUPT_DRUGS_MEDICAM – Localized skin eruption due to drugs and medicaments
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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