No definition available.
Generalized skin eruption due to drugs and medicaments
GENERALI_SKIN_ERUPT_DRUGS_MEDICAM
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
1320 |
4. Check minimum number of eventsNone |
1320 |
5. Include endpointsNone |
1320 |
6. Filter based on genotype QC (FinnGen only) |
1279 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5
Similar endpoints
↥List of similar endpoints to
Generalized skin eruption due to drugs and medicaments
based on the number of shared cases.
Similar with more cases:
- Acute generalized exanthematous pustulosis
- Dermatitis due to substances taken internally
- Dermatitis and eczema
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 11054 | 6550 | 4445 |
| Only index persons | 9672 | 5844 | 3828 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.19 | 0.12 |
| Only index persons | 0.19 | 0.21 | 0.15 |
| Median age at first event (years) | |||
| Whole population | 49.28 | 52.61 | 44.11 |
| Only index persons | 48.96 | 51.80 | 44.62 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1279 | 845 | 434 |
| Unadjusted period prevalence (%) | 0.29 | 0.33 | 0.22 |
| Median age at first event (years) | 55.82 | 52.91 | 61.48 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint GENERALI_SKIN_ERUPT_DRUGS_MEDICAM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| GENERALI_SKIN_ERUPT_DRUGS_MEDICAM | 1.819 [1.6, 2.07] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.29 |
During the follow-up period (1.1.1998 — 31.12.2019), 1245 out of 5640 females with GENERALI_SKIN_ERUPT_DRUGS_MEDICAM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| GENERALI_SKIN_ERUPT_DRUGS_MEDICAM | 2.073 [1.77, 2.43] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 840 out of 3833 males with GENERALI_SKIN_ERUPT_DRUGS_MEDICAM died.
Mortality risk
Mortality risk for people of age
years, who have GENERALI_SKIN_ERUPT_DRUGS_MEDICAM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.171% | 0.399% |
| 5 | 0.945% | 2.288% |
| 10 | 2.696% | 5.745% |
| 15 | 5.097% | 10.828% |
| 20 | 8.893% | 17.877% |
Relationships between endpoints
↥Index endpoint: GENERALI_SKIN_ERUPT_DRUGS_MEDICAM – Generalized skin eruption due to drugs and medicaments
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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