hidradenitis suppurativa: a common (though rarely diagnosed), chronic skin disease characterized by clusters of abscesses or subcutaneous boil-like "infections" (oftentimes free of actual bacteria) that most commonly affects apocrine sweat gland bearing areas, such as the underarms, under the breasts, inner thighs, groin and buttocks.The disease is not contagious. There are indications that it is hereditary among certain ethnic groups and autoimmune in nature. Onset is most common in the late teens and early 20's.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1262 |
4. Check minimum number of eventsNone |
1262 |
5. Include endpointsNone |
1262 |
6. Filter based on genotype QC (FinnGen only) |
1209 |
Control definitions (FinnGen only)
Control exclude
L12_DISORDSKINAPPENDIX
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L73
Name in latin
Hidradenitis suppurativa
Similar endpoints
↥List of similar endpoints to
Hidradenitis suppurativa
based on the number of shared cases.
Similar with more cases:
- Other follicular disorders
- Disorders of skin appendages
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7919 | 4721 | 3160 |
| Only index persons | 7639 | 4620 | 3019 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.14 | 0.09 |
| Only index persons | 0.15 | 0.17 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 38.04 | 36.15 | 40.86 |
| Only index persons | 37.79 | 36.01 | 40.52 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1209 | 843 | 366 |
| Unadjusted period prevalence (%) | 0.29 | 0.33 | 0.18 |
| Median age at first event (years) | 40.38 | 38.02 | 45.82 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_HIDRADENITISSUP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_HIDRADENITISSUP | 2.542 [2.09, 3.09] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.08 |
During the follow-up period (1.1.1998 — 31.12.2019), 168 out of 3437 females with L12_HIDRADENITISSUP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_HIDRADENITISSUP | 2.558 [2.19, 2.99] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 286 out of 2336 males with L12_HIDRADENITISSUP died.
Mortality risk
Mortality risk for people of age
years, who have L12_HIDRADENITISSUP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.225% | 0.52% |
| 5 | 1.414% | 2.929% |
| 10 | 3.201% | 7.481% |
| 15 | 6.359% | 14.047% |
| 20 | 11.188% | 22.631% |
Relationships between endpoints
↥Index endpoint: L12_HIDRADENITISSUP – Hidradenitis suppurativa
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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