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Other and unspecified follicular disorders

DOID EFO Endpoint Browser PheWeb

L12_FOLLICULARNAS

folliculitis: the infection and inflammation of one or more hair follicles. The condition may occur anywhere on the skin with the exception of the palms of the hands and soles of the feet. The rash may appear as pimples that come to white tips on the face, chest, back, arms, legs, and head.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L73.8, L73.9
  • Hospital discharge: ICD-9 — 7069
  • Hospital discharge: ICD-8 — 706[3-9]
  • Cause of death: ICD-10 — L73.8, L73.9
  • Cause of death: ICD-9 — 7069
  • Cause of death: ICD-8 — 706[3-9]

2 out of 7 registries used, show all original rules.

1298

4. Check minimum number of events

None

1298

5. Include endpoints

None

1298

6. Filter based on genotype QC (FinnGen only)

1238

Control definitions (FinnGen only)

Control exclude L12_DISORDSKINAPPENDIX

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8603 3753 4790
Only index persons 8112 3612 4500
Unadjusted period prevalence (%)
Whole population 0.12 0.11 0.13
Only index persons 0.15 0.13 0.17
Median age at first event (years)
Whole population 43.73 40.91 46.02
Only index persons 43.59 40.82 45.81

-FinnGen-

Key figures

All Female Male
Number of individuals 1238 586 652
Unadjusted period prevalence (%) 0.28 0.23 0.33
Median age at first event (years) 49.01 44.15 53.38

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint L12_FOLLICULARNAS and mortality.

Females

Parameter HR [95% CI] p-value
L12_FOLLICULARNAS 1.516 [1.26, 1.83] < 0.001
Birth year 0.991 [0.98, 1.0] 0.057

During the follow-up period (1.1.1998 — 31.12.2019), 214 out of 2779 females with L12_FOLLICULARNAS died.

Males

Parameter HR [95% CI] p-value
L12_FOLLICULARNAS 1.242 [1.05, 1.46] 0.009
Birth year 0.985 [0.98, 0.99] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 429 out of 3435 males with L12_FOLLICULARNAS died.

Mortality risk

Mortality risk for people of age

years, who have L12_FOLLICULARNAS.

N-year risk Females Males
1 0.166% 0.236%
5 0.812% 1.421%
10 1.979% 3.469%
15 3.771% 6.68%
20 6.491% 10.955%

Relationships between endpoints

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Index endpoint: L12_FOLLICULARNAS – Other and unspecified follicular disorders

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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