No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
KRA_PSY_ANYMENTAL
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F80-F89
Name in latin
Perturbatio specifica progressus functionis motoricae
Similar endpoints
↥List of similar endpoints to
Motor disorders
based on the number of shared cases.
Similar with more cases:
- Specific developmental disorder of motor function
- Motor disorders
- Disorders of psychological development
- Any mental disorder
- Psychiatric diseases
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 19285 | 5193 | 14091 |
| Only index persons | 14350 | 3746 | 10604 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.33 | 0.15 | 0.39 |
| Only index persons | 0.34 | 0.14 | 0.40 |
| Median age at first event (years) | |||
| Whole population | 5.64 | 5.23 | 5.79 |
| Only index persons | 6.01 | 5.73 | 6.11 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 511 | 215 | 296 |
| Unadjusted period prevalence (%) | 0.12 | 0.08 | 0.15 |
| Median age at first event (years) | 6.07 | 6.05 | 6.08 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint KRA_PSY_MOTOR_EXMORE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| KRA_PSY_MOTOR_EXMORE | 5.423 [3.53, 8.32] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.718 |
During the follow-up period (1.1.1998 — 31.12.2019), 51 out of 4619 females with KRA_PSY_MOTOR_EXMORE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| KRA_PSY_MOTOR_EXMORE | 1.391 [1.09, 1.78] | 0.009 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 74 out of 12381 males with KRA_PSY_MOTOR_EXMORE died.
Mortality risk
Mortality risk for people of age
years, who have KRA_PSY_MOTOR_EXMORE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.535% | 0.22% |
| 5 | 3.684% | 1.348% |
| 10 | 8.492% | 3.597% |
| 15 | 15.025% | 6.466% |
| 20 | 25.122% | 10.711% |
Relationships between endpoints
↥Index endpoint: KRA_PSY_MOTOR_EXMORE – Motor disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data