No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
KRA_PSY_ANYMENTAL
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Autism spe
based on the number of shared cases.
Similar with more cases:
- Autism spe
- Autism
- Wide developmental disorders
- Wide developmental disorders
- Disorders of psychological development
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 20159 | 5762 | 14375 |
| Only index persons | 17495 | 5180 | 12315 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.33 | 0.17 | 0.40 |
| Only index persons | 0.39 | 0.19 | 0.47 |
| Median age at first event (years) | |||
| Whole population | 12.63 | 15.83 | 11.31 |
| Only index persons | 13.67 | 16.33 | 12.55 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 767 | 350 | 417 |
| Unadjusted period prevalence (%) | 0.18 | 0.14 | 0.21 |
| Median age at first event (years) | 23.50 | 25.80 | 21.57 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint KRA_PSY_AUTISM_EXMORE and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| KRA_PSY_AUTISM_EXMORE | 1.917 [1.57, 2.35] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 134 out of 11396 males with KRA_PSY_AUTISM_EXMORE died.
Mortality risk
Mortality risk for people of age
years, who have KRA_PSY_AUTISM_EXMORE.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.377% |
| 5 | No data | 2.083% |
| 10 | No data | 5.188% |
| 15 | No data | 9.556% |
| 20 | No data | 15.657% |
Relationships between endpoints
↥Index endpoint: KRA_PSY_AUTISM_EXMORE – Autism spe
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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