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Any mental disorder, or suicide (or attempt), or psychic disorders complicating pregnancy, partum or puerperum or nerve system disorders

Endpoint Browser PheWeb

KRA_PSY_ANYMENTAL_SUICID_PREG_NERV_EXMORE

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — O99.3
  • Hospital discharge: ICD-9 — 6484X
  • Cause of death: ICD-10 — O99.3
  • Cause of death: ICD-9 — 6484X

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude KRA_PSY_ANYMENTAL

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 O99
Name in latin Perturbationes psychicae et morbi systematis nervosi complicantes graviditatem, partum et puerperium

Similar endpoints

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List of similar endpoints to Any mental disorder, or suicide (or attempt), or psychic disorders complicating pregnancy, partum or puerperum or nerve system disorders based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

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FinnGen case counts by registry codes:

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Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 156606 76311 78204
Only index persons 108675 65093 43582
Unadjusted period prevalence (%)
Whole population 2.19 2.19 2.19
Only index persons 2.10 2.39 1.66
Median age at first event (years)
Whole population 35.21 32.22 37.86
Only index persons 32.84 30.95 35.68

-FinnGen-

Key figures

All Female Male
Number of individuals 12933 8684 4249
Unadjusted period prevalence (%) 2.99 3.41 2.13
Median age at first event (years) 33.69 31.41 38.34

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint KRA_PSY_ANYMENTAL_SUICID_PREG_NERV_EXMORE and mortality.

Females

Parameter HR [95% CI] p-value
KRA_PSY_ANYMENTAL_SUICID_PREG_NERV_EXMORE 3.599 [3.2, 4.05] < 0.001
Birth year 0.998 [0.99, 1.01] 0.633

During the follow-up period (1.1.1998 — 31.12.2019), 4867 out of 51839 females with KRA_PSY_ANYMENTAL_SUICID_PREG_NERV_EXMORE died.

Males

Parameter HR [95% CI] p-value
KRA_PSY_ANYMENTAL_SUICID_PREG_NERV_EXMORE 4.923 [4.41, 5.5] < 0.001
Birth year 0.989 [0.98, 1.0] 0.01

During the follow-up period (1.1.1998 — 31.12.2019), 7575 out of 33178 males with KRA_PSY_ANYMENTAL_SUICID_PREG_NERV_EXMORE died.

Mortality risk

Mortality risk for people of age

years, who have KRA_PSY_ANYMENTAL_SUICID_PREG_NERV_EXMORE.

N-year risk Females Males
1 0.315% 0.775%
5 2.143% 5.021%
10 5.17% 12.617%
15 10.546% 23.622%
20 17.883% 37.915%

Relationships between endpoints

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Index endpoint: KRA_PSY_ANYMENTAL_SUICID_PREG_NERV_EXMORE – Any mental disorder, or suicide (or attempt), or psychic disorders complicating pregnancy, partum or puerperum or nerve system disorders

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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