No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
26974 |
4. Check minimum number of eventsNone |
26974 |
5. Include endpointsNone |
26974 |
6. Filter based on genotype QC (FinnGen only) |
26134 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
First used in FinnGen datafreeze
DF3
KELA_REIMBURSEMENT_202
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 185643 | 118766 | 65381 |
| Only index persons | 152213 | 98524 | 53689 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.83 | 3.40 | 1.83 |
| Only index persons | 3.07 | 3.62 | 2.05 |
| Median age at first event (years) | |||
| Whole population | 50.41 | 50.90 | 49.45 |
| Only index persons | 48.67 | 49.22 | 47.66 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 26134 | 17004 | 9130 |
| Unadjusted period prevalence (%) | 5.95 | 6.68 | 4.59 |
| Median age at first event (years) | 48.00 | 46.91 | 50.02 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_REIMB_202 and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_REIMB_202 | 1.314 [1.22, 1.42] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.017 |
During the follow-up period (1.1.1998 — 31.12.2019), 8245 out of 64395 females with K11_REIMB_202 died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_REIMB_202 | 1.311 [1.21, 1.43] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 6319 out of 37085 males with K11_REIMB_202 died.
Mortality risk
Mortality risk for people of age
years, who have K11_REIMB_202.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.107% | 0.247% |
| 5 | 0.617% | 1.376% |
| 10 | 1.571% | 3.463% |
| 15 | 2.981% | 6.795% |
| 20 | 5.143% | 11.778% |
Relationships between endpoints
↥Index endpoint: K11_REIMB_202 – KELA_REIMBURSEMENT_202
GWS hits: 40
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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