ulcerative colitis: An inflammatory bowel disease involving the mucosal surface of the large intestine and rectum. It may present with an acute or slow onset and follows an intermittent or continuous course. Signs and symptoms include abdominal pain, diarrhea, fever, weight loss, and intestinal hemorrhage.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
267 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
267 |
6. Filter based on genotype QC (FinnGen only) |
261 |
Control definitions (FinnGen only)
Control exclude
K11_IBD, K11_CHOLANGI
Control conditions
not K11_CHOLANGI_STRICT
and not K11_UC_STRICT
and not K11_UC_STRICT
Extra metadata
First used in FinnGen datafreeze
DF4
Similar endpoints
↥List of similar endpoints to
Ulcerative colitis (strict) with PSC
based on the number of shared cases.
Similar with more cases:
- IBD (strict) with PSC
- Colitis, primary sclerosing
- Cholangitis (primary sclerosing, PSC), with reimbursement 202
- Cholangitis (primary sclerosing, PSC)
- Ulcerative colitis (strict definition, require KELA)
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 896 | 350 | 542 |
| Only index persons | 876 | 342 | 534 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.02 |
| Only index persons | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 26.31 | 27.84 | 25.12 |
| Only index persons | 26.07 | 27.64 | 25.07 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 261 | 124 | 137 |
| Unadjusted period prevalence (%) | 0.06 | 0.05 | 0.07 |
| Median age at first event (years) | 26.66 | 26.84 | 26.49 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint K11_UC_STRICT_PSC and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have K11_UC_STRICT_PSC.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: K11_UC_STRICT_PSC – Ulcerative colitis (strict) with PSC
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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