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Periodontal disease, other/unspecified

Endpoint Browser PheWeb

K11_PERIODONTAL_NOS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K05.5, K05.6
  • Hospital discharge: ICD-9 — 523[6-9]
  • Hospital discharge: ICD-8 — 523[6-9]
  • Cause of death: ICD-10 — K05.5, K05.6
  • Cause of death: ICD-9 — 523[6-9]
  • Cause of death: ICD-8 — 523[6-9]

2 out of 7 registries used, show all original rules.

117

4. Check minimum number of events

None

117

5. Include endpoints

None

117

6. Filter based on genotype QC (FinnGen only)

112

Control definitions (FinnGen only)

Control exclude K11_GINGIVITIS_PERIODONTAL

Extra metadata

First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1191 575 607
Only index persons 1018 487 531
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 45.87 49.92 41.85
Only index persons 43.14 47.83 38.84

-FinnGen-

Key figures

All Female Male
Number of individuals 112 55 57
Unadjusted period prevalence (%) 0.03 0.02 0.03
Median age at first event (years) 54.52 52.21 56.75

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint K11_PERIODONTAL_NOS and mortality.

Females

Parameter HR [95% CI] p-value
K11_PERIODONTAL_NOS 1.776 [1.09, 2.88] 0.02
Birth year 0.995 [0.99, 1.0] 0.252

During the follow-up period (1.1.1998 — 31.12.2019), 60 out of 350 females with K11_PERIODONTAL_NOS died.

Males

Parameter HR [95% CI] p-value
K11_PERIODONTAL_NOS 2.488 [1.67, 3.72] < 0.001
Birth year 0.989 [0.98, 1.0] 0.025

During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 352 males with K11_PERIODONTAL_NOS died.

Mortality risk

Mortality risk for people of age

years, who have K11_PERIODONTAL_NOS.

N-year risk Females Males
1 0.191% 0.469%
5 0.983% 2.888%
10 2.583% 7.357%
15 5.177% 13.92%
20 9.002% 22.794%

Relationships between endpoints

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Index endpoint: K11_PERIODONTAL_NOS – Periodontal disease, other/unspecified

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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