Dental caries 1 and operation codes, only avohilmo

K11_CARIES_1_OPER_ONLYAVO

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

  • K11_DENTAL_OPER_ONLYAVO
247059

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

186416

6. Filter based on genotype QC (FinnGen only)

179189

Control definitions (FinnGen only)

Control conditions K11_DENTAL_OPER

Extra metadata

First used in FinnGen datafreeze DF7

Case counts by codes

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1978827 1055614 913650
Only index persons 1873922 1009115 864807
Unadjusted period prevalence (%)
Whole population 27.96 30.24 25.53
Only index persons 35.21 37.10 33.01
Median age at first event (years)
Whole population 35.88 36.96 34.67
Only index persons 37.70 38.55 36.71

-FinnGen-

Key figures

All Female Male
Number of individuals 179189 111987 67202
Unadjusted period prevalence (%) 40.15 43.98 33.75
Median age at first event (years) 51.07 48.43 55.47

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint K11_CARIES_1_OPER_ONLYAVO and mortality.

Females

Parameter HR [95% CI] p-value
K11_CARIES_1_OPER_ONLYAVO 0.715 [0.61, 0.84] < 0.001
Birth year 0.999 [0.99, 1.01] 0.763

During the follow-up period (1.1.1998 — 31.12.2019), 17682 out of 947023 females with K11_CARIES_1_OPER_ONLYAVO died.

Males

Parameter HR [95% CI] p-value
K11_CARIES_1_OPER_ONLYAVO 0.752 [0.64, 0.89] < 0.001
Birth year 0.989 [0.98, 1.0] 0.014

During the follow-up period (1.1.1998 — 31.12.2019), 22048 out of 814009 males with K11_CARIES_1_OPER_ONLYAVO died.

Mortality risk

Mortality risk for people of age

years, who have K11_CARIES_1_OPER_ONLYAVO.

N-year risk Females Males
1 0.071% 0.107%
5 0.482% 0.842%
10 1.062% 2.137%
15 2.169% 4.107%
20 3.87% 7.219%

Relationships between endpoints

Index endpoint: K11_CARIES_1_OPER_ONLYAVO – Dental caries 1 and operation codes, only avohilmo

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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