Dental caries 2 and operation codes, only avohilmo

K11_CARIES_2_OPER_ONLYAVO

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

  • K11_DENTAL_OPER_ONLYAVO
247059

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

36822

6. Filter based on genotype QC (FinnGen only)

35302

Control definitions (FinnGen only)

Control conditions K11_DENTAL_OPER

Extra metadata

First used in FinnGen datafreeze DF7

Case counts by codes

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 417740 234443 181938
Only index persons 382635 217799 164836
Unadjusted period prevalence (%)
Whole population 5.99 6.72 5.08
Only index persons 7.27 8.01 6.29
Median age at first event (years)
Whole population 21.49 24.87 17.04
Only index persons 23.23 27.21 17.96

-FinnGen-

Key figures

All Female Male
Number of individuals 35302 24489 10813
Unadjusted period prevalence (%) 8.34 9.62 5.43
Median age at first event (years) 46.06 43.37 52.14

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint K11_CARIES_2_OPER_ONLYAVO and mortality.

Females

Parameter HR [95% CI] p-value
K11_CARIES_2_OPER_ONLYAVO 0.687 [0.48, 0.97] 0.036
Birth year 0.991 [0.98, 1.0] 0.047

During the follow-up period (1.1.1998 — 31.12.2019), 854 out of 168812 females with K11_CARIES_2_OPER_ONLYAVO died.

Males

Parameter HR [95% CI] p-value
K11_CARIES_2_OPER_ONLYAVO 0.863 [0.58, 1.29] 0.474
Birth year 0.991 [0.98, 1.0] 0.05

During the follow-up period (1.1.1998 — 31.12.2019), 993 out of 130358 males with K11_CARIES_2_OPER_ONLYAVO died.

Mortality risk

Mortality risk for people of age

years, who have K11_CARIES_2_OPER_ONLYAVO.

N-year risk Females Males
1 0.061% 0.169%
5 0.332% 0.983%
10 0.938% 2.706%
15 1.731% 5.228%
20 2.937% 8.869%

Relationships between endpoints

Index endpoint: K11_CARIES_2_OPER_ONLYAVO – Dental caries 2 and operation codes, only avohilmo

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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