Dental caries 3 and operation codes, only avohilmo

K11_CARIES_3_OPER_ONLYAVO

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

  • K11_DENTAL_OPER_ONLYAVO
247059

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

174646

6. Filter based on genotype QC (FinnGen only)

167911

Control definitions (FinnGen only)

Control conditions K11_DENTAL_OPER

Extra metadata

First used in FinnGen datafreeze DF7

Case counts by codes

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1816427 964972 842425
Only index persons 1727776 926280 801496
Unadjusted period prevalence (%)
Whole population 25.65 27.64 23.54
Only index persons 32.45 34.05 30.60
Median age at first event (years)
Whole population 37.11 38.09 36.04
Only index persons 38.75 39.53 37.85

-FinnGen-

Key figures

All Female Male
Number of individuals 167911 104134 63777
Unadjusted period prevalence (%) 37.53 40.90 32.03
Median age at first event (years) 51.50 48.87 55.80

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint K11_CARIES_3_OPER_ONLYAVO and mortality.

Females

Parameter HR [95% CI] p-value
K11_CARIES_3_OPER_ONLYAVO 0.773 [0.65, 0.92] 0.003
Birth year 0.996 [0.99, 1.0] 0.272

During the follow-up period (1.1.1998 — 31.12.2019), 16544 out of 868402 females with K11_CARIES_3_OPER_ONLYAVO died.

Males

Parameter HR [95% CI] p-value
K11_CARIES_3_OPER_ONLYAVO 0.731 [0.61, 0.87] < 0.001
Birth year 0.988 [0.98, 1.0] 0.011

During the follow-up period (1.1.1998 — 31.12.2019), 20723 out of 752181 males with K11_CARIES_3_OPER_ONLYAVO died.

Mortality risk

Mortality risk for people of age

years, who have K11_CARIES_3_OPER_ONLYAVO.

N-year risk Females Males
1 0.051% 0.12%
5 0.365% 0.781%
10 0.998% 2.064%
15 2.072% 4.031%
20 3.689% 6.841%

Relationships between endpoints

Index endpoint: K11_CARIES_3_OPER_ONLYAVO – Dental caries 3 and operation codes, only avohilmo

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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