appendicitis: Acute inflammation of the vermiform appendix.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
36302 |
4. Check minimum number of eventsNone |
36302 |
5. Include endpointsNone |
36302 |
6. Filter based on genotype QC (FinnGen only) |
35180 |
Control definitions (FinnGen only)
Control exclude
K11_APPENDIX
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K35-K38
Name in latin
Appendicitis acuta
Similar endpoints
↥List of similar endpoints to
Acute appendicitis
based on the number of shared cases.
Similar with more cases:
- Appendicitis, broad definition
- Diseases of appendix
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 338518 | 157317 | 179425 |
| Only index persons | 312186 | 147834 | 164352 |
| Unadjusted period prevalence (%) | |||
| Whole population | 4.76 | 4.51 | 5.01 |
| Only index persons | 5.88 | 5.43 | 6.27 |
| Median age at first event (years) | |||
| Whole population | 29.24 | 28.86 | 29.42 |
| Only index persons | 28.24 | 28.11 | 28.36 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 35180 | 19134 | 16046 |
| Unadjusted period prevalence (%) | 7.76 | 7.51 | 8.06 |
| Median age at first event (years) | 31.54 | 29.21 | 34.31 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_APPENDACUT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_APPENDACUT | 1.04 [0.94, 1.15] | 0.452 |
| Birth year | 0.992 [0.98, 1.0] | 0.047 |
During the follow-up period (1.1.1998 — 31.12.2019), 3836 out of 74170 females with K11_APPENDACUT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_APPENDACUT | 0.96 [0.87, 1.05] | 0.385 |
| Birth year | 0.987 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 5402 out of 79336 males with K11_APPENDACUT died.
Mortality risk
Mortality risk for people of age
years, who have K11_APPENDACUT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.107% | 0.16% |
| 5 | 0.608% | 1.077% |
| 10 | 1.396% | 2.715% |
| 15 | 2.749% | 5.118% |
| 20 | 4.811% | 8.874% |
Relationships between endpoints
↥Index endpoint: K11_APPENDACUT – Acute appendicitis
GWS hits: 22
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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