appendicitis: Acute inflammation of the vermiform appendix.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
465314 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
27935 |
6. Filter based on genotype QC (FinnGen only) |
27076 |
Control definitions (FinnGen only)
Control exclude
K11_APPENDIX
Control conditions
not APPENDACUT_COMPLIC
Extra metadata
First used in FinnGen datafreeze
DF3
Similar endpoints
↥List of similar endpoints to
Acute appendicitis, no complications
based on the number of shared cases.
Similar with more cases:
- Acute appendicitis
- Appendicitis, broad definition
- Diseases of appendix
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 254473 | 120439 | 132865 |
| Only index persons | 239584 | 115012 | 124572 |
| Unadjusted period prevalence (%) | |||
| Whole population | 3.58 | 3.45 | 3.71 |
| Only index persons | 4.50 | 4.23 | 4.76 |
| Median age at first event (years) | |||
| Whole population | 28.30 | 27.95 | 28.53 |
| Only index persons | 27.79 | 27.59 | 27.99 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 27076 | 15241 | 11835 |
| Unadjusted period prevalence (%) | 5.97 | 5.99 | 5.94 |
| Median age at first event (years) | 31.01 | 28.90 | 33.73 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint APPENDACUT_NOCOMPLIC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| APPENDACUT_NOCOMPLIC | 0.945 [0.85, 1.05] | 0.314 |
| Birth year | 0.993 [0.98, 1.0] | 0.085 |
During the follow-up period (1.1.1998 — 31.12.2019), 2511 out of 61090 females with APPENDACUT_NOCOMPLIC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| APPENDACUT_NOCOMPLIC | 0.947 [0.86, 1.04] | 0.256 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 3687 out of 64898 males with APPENDACUT_NOCOMPLIC died.
Mortality risk
Mortality risk for people of age
years, who have APPENDACUT_NOCOMPLIC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.08% | 0.131% |
| 5 | 0.538% | 1.025% |
| 10 | 1.26% | 2.682% |
| 15 | 2.465% | 5.147% |
| 20 | 4.299% | 8.752% |
Relationships between endpoints
↥Index endpoint: APPENDACUT_NOCOMPLIC – Acute appendicitis, no complications
GWS hits: 9
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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