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Acute appendicitis, with complications

DOID EFO Endpoint Browser PheWeb

APPENDACUT_COMPLIC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K35.0, K35.1
  • Hospital discharge: ICD-9 — 540[0-1]
  • Hospital discharge: ICD-8 — 540
  • Hospital discharge: excluded ICD-8 — 54090|54099
  • Cause of death: ICD-10 — K35.0, K35.1
  • Cause of death: ICD-9 — 540[0-1]
  • Cause of death: ICD-8 — 540
  • Cause of death: excluded ICD-8 — 54090|54099

2 out of 7 registries used, show all original rules.

8367

4. Check minimum number of events

None

8367

5. Include endpoints

None

8367

6. Filter based on genotype QC (FinnGen only)

8104

Control definitions (FinnGen only)

Control exclude K11_APPENDIX

Extra metadata

First used in FinnGen datafreeze DF3

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 84045 36878 46560
Only index persons 72602 32822 39780
Unadjusted period prevalence (%)
Whole population 1.19 1.06 1.30
Only index persons 1.38 1.21 1.52
Median age at first event (years)
Whole population 33.29 33.34 32.99
Only index persons 30.31 30.74 29.95

-FinnGen-

Key figures

All Female Male
Number of individuals 8104 3893 4211
Unadjusted period prevalence (%) 1.83 1.53 2.11
Median age at first event (years) 33.63 30.79 36.26

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint APPENDACUT_COMPLIC and mortality.

Females

Parameter HR [95% CI] p-value
APPENDACUT_COMPLIC 1.249 [1.12, 1.4] < 0.001
Birth year 0.992 [0.98, 1.0] 0.049

During the follow-up period (1.1.1998 — 31.12.2019), 1325 out of 13079 females with APPENDACUT_COMPLIC died.

Males

Parameter HR [95% CI] p-value
APPENDACUT_COMPLIC 1.119 [1.01, 1.25] 0.04
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 1714 out of 14440 males with APPENDACUT_COMPLIC died.

Mortality risk

Mortality risk for people of age

years, who have APPENDACUT_COMPLIC.

N-year risk Females Males
1 0.088% 0.216%
5 0.567% 1.277%
10 1.541% 3.117%
15 2.994% 5.806%
20 5.332% 10.039%

Relationships between endpoints

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Index endpoint: APPENDACUT_COMPLIC – Acute appendicitis, with complications

GWS hits: 5

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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