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Vascular diseases of the intestine

DOID EFO Endpoint Browser PheWeb

I9_VASCINT

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K55.0, K55.1, K55.9
  • Hospital discharge: ICD-9 — 557
  • Hospital discharge: ICD-8 — 4442
  • Cause of death: ICD-10 — K55.0, K55.1, K55.9
  • Cause of death: ICD-9 — 557
  • Cause of death: ICD-8 — 4442

2 out of 7 registries used, show all original rules.

1219

4. Check minimum number of events

None

1219

5. Include endpoints

None

1219

6. Filter based on genotype QC (FinnGen only)

1179

Control definitions (FinnGen only)

Control exclude I9_DOAAC

Extra metadata

First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 15849 8537 7057
Only index persons 9760 5453 4307
Unadjusted period prevalence (%)
Whole population 0.22 0.24 0.20
Only index persons 0.18 0.20 0.16
Median age at first event (years)
Whole population 75.47 78.24 72.18
Only index persons 74.62 77.46 71.02

-FinnGen-

Key figures

All Female Male
Number of individuals 1179 509 670
Unadjusted period prevalence (%) 0.28 0.20 0.34
Median age at first event (years) 71.57 71.17 71.87

-FinRegistry-

Age distribution of first events

01020304050607080900.0k0.5k1.0k1.5k2.0k2.5k3.0k3.5k4.0k4.5kAgeIndividuals

-FinnGen-

Age distribution of first events

02030405060708090050100150200250300350400AgeIndividuals

-FinRegistry-

Year distribution of first events

197519801985199019952000200520102015202020220.0k0.5k1.0k1.5k2.0k2.5k3.0kYearIndividuals

-FinnGen-

Year distribution of first events

1970197519901995200020052010201520202023020406080100120140160180200220240260280300YearIndividuals

-FinRegistry-

Cumulative Incidence Function

01020304050607080901000.00.20.40.60.81.01.21.41.61.82.0AgeProbability of first incidence (%)

-FinnGen-

Cumulative Incidence Function

01020304050607080901000.00.20.40.60.81.01.21.41.61.82.0AgeProbability of first incidence (%)

Mortality – FinRegistry

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Association

Association between endpoint I9_VASCINT and mortality.

Females

Parameter HR [95% CI] p-value
I9_VASCINT 2.358 [2.04, 2.73] < 0.001
Birth year 0.992 [0.98, 1.0] 0.054

During the follow-up period (1.1.1998 — 31.12.2019), 1634 out of 3488 females with I9_VASCINT died.

Males

Parameter HR [95% CI] p-value
I9_VASCINT 2.534 [2.12, 3.02] < 0.001
Birth year 0.984 [0.97, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 1385 out of 2889 males with I9_VASCINT died.

Mortality risk

Mortality risk for people of age

years, who have I9_VASCINT.

N-year risk Females Males
1 0.273% 0.507%
5 1.464% 2.781%
10 3.416% 6.731%
15 6.066% 12.717%
20 10.237% 20.258%

Relationships between endpoints

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Index endpoint: I9_VASCINT – Vascular diseases of the intestine

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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