heart aneurysm: A localized bulging or dilatation in the muscle wall of a heart (myocardium), usually in the left ventricle. Blood-filled aneurysms are dangerous because they may burst. Fibrous aneurysms interfere with the heart function through the loss of contractility. True aneurysm is bound by the vessel wall or cardiac wall. False aneurysms are hematoma caused by myocardial rupture.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3622 |
4. Check minimum number of eventsNone |
3622 |
5. Include endpointsNone |
3622 |
6. Filter based on genotype QC (FinnGen only) |
3499 |
Control definitions (FinnGen only)
Control exclude
I9_ISCHHEART
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
I25
Name in latin
Aneurysma cordis
Similar endpoints
↥List of similar endpoints to
Status post-ami
based on the number of shared cases.
Similar with more cases:
- Ischaemic heart disease, wide definition
- Ischemic heart diseases
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 108486 | 33890 | 70276 |
| Only index persons | 20386 | 6515 | 13871 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.75 | 0.97 | 1.96 |
| Only index persons | 0.44 | 0.24 | 0.53 |
| Median age at first event (years) | |||
| Whole population | 63.64 | 67.62 | 61.78 |
| Only index persons | 54.84 | 56.89 | 53.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3499 | 589 | 2910 |
| Unadjusted period prevalence (%) | 1.25 | 0.23 | 1.46 |
| Median age at first event (years) | 56.65 | 56.75 | 56.63 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint I9_POSTAMI and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_POSTAMI | 2.158 [1.51, 3.09] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.454 |
During the follow-up period (1.1.1998 — 31.12.2019), 115 out of 213 females with I9_POSTAMI died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_POSTAMI | 1.663 [1.27, 2.18] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.021 |
During the follow-up period (1.1.1998 — 31.12.2019), 177 out of 339 males with I9_POSTAMI died.
Mortality risk
Mortality risk for people of age
years, who have I9_POSTAMI.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.235% | 0.351% |
| 5 | 1.194% | 2.352% |
| 10 | 2.973% | 5.284% |
| 15 | 5.86% | 9.591% |
| 20 | 10.41% | 16.394% |
Relationships between endpoints
↥Index endpoint: I9_POSTAMI – Status post-ami
GWS hits: 7
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data