myocardial infarction: Gross necrosis of the myocardium, as a result of interruption of the blood supply to the area, as in coronary thrombosis.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
276 |
4. Check minimum number of eventsNone |
276 |
5. Include endpointsNone |
276 |
6. Filter based on genotype QC (FinnGen only) |
264 |
Control definitions (FinnGen only)
Control exclude
I9_ISCHHEART
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
I20-I25
Name in latin
Aliquae complicationes post infarctum myocardii acutum
Similar endpoints
↥List of similar endpoints to
Complications following myocardial infarction
based on the number of shared cases.
Similar with more cases:
- Ischaemic heart disease, wide definition
- Ischemic heart diseases
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4502 | 1945 | 2459 |
| Only index persons | 2275 | 934 | 1341 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.06 | 0.07 |
| Only index persons | 0.04 | 0.03 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 74.10 | 77.64 | 71.22 |
| Only index persons | 72.79 | 77.27 | 69.66 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 264 | 71 | 193 |
| Unadjusted period prevalence (%) | 0.08 | 0.03 | 0.10 |
| Median age at first event (years) | 70.39 | 69.59 | 70.69 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint I9_MI_COMPLICATIONS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_MI_COMPLICATIONS | 2.357 [1.88, 2.95] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.801 |
During the follow-up period (1.1.1998 — 31.12.2019), 329 out of 499 females with I9_MI_COMPLICATIONS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_MI_COMPLICATIONS | 2.412 [1.98, 2.93] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 427 out of 704 males with I9_MI_COMPLICATIONS died.
Mortality risk
Mortality risk for people of age
years, who have I9_MI_COMPLICATIONS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.256% | 0.471% |
| 5 | 1.612% | 2.737% |
| 10 | 4.016% | 6.797% |
| 15 | 7.708% | 13.221% |
| 20 | 13.262% | 21.439% |
Relationships between endpoints
↥Index endpoint: I9_MI_COMPLICATIONS – Complications following myocardial infarction
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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