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Hypotension

DOID EFO Endpoint Browser PheWeb

I9_HYPOTE

hypertension: Persistently high systemic arterial blood pressure. Based on multiple readings (blood pressure determination), hypertension is currently defined as when systolic pressure is consistently greater than 140 mm Hg or when diastolic pressure is consistently 90 mm Hg or more.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I95
  • Hospital discharge: ICD-9 — 458
  • Hospital discharge: ICD-8 — 4580
  • Cause of death: ICD-10 — I95
  • Cause of death: ICD-9 — 458
  • Cause of death: ICD-8 — 4580

2 out of 7 registries used, show all original rules.

5820

4. Check minimum number of events

None

5820

5. Include endpoints

None

5820

6. Filter based on genotype QC (FinnGen only)

5622

Control definitions (FinnGen only)

Control exclude I9_OTH

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I95-I99
Name in latin Hypotensio (arterialis)

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 60503 31758 28282
Only index persons 50400 26909 23491
Unadjusted period prevalence (%)
Whole population 0.85 0.91 0.79
Only index persons 0.95 0.99 0.90
Median age at first event (years)
Whole population 78.05 79.81 76.14
Only index persons 78.34 80.16 76.25

-FinnGen-

Key figures

All Female Male
Number of individuals 5622 2371 3251
Unadjusted period prevalence (%) 1.34 0.93 1.63
Median age at first event (years) 74.23 73.31 74.90

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint I9_HYPOTE and mortality.

Females

Parameter HR [95% CI] p-value
I9_HYPOTE 1.758 [1.57, 1.96] < 0.001
Birth year 0.997 [0.99, 1.0] 0.434

During the follow-up period (1.1.1998 — 31.12.2019), 11874 out of 23909 females with I9_HYPOTE died.

Males

Parameter HR [95% CI] p-value
I9_HYPOTE 2.438 [2.1, 2.83] < 0.001
Birth year 0.989 [0.98, 1.0] 0.013

During the follow-up period (1.1.1998 — 31.12.2019), 11568 out of 21100 males with I9_HYPOTE died.

Mortality risk

Mortality risk for people of age

years, who have I9_HYPOTE.

N-year risk Females Males
1 0.173% 0.49%
5 1.198% 2.891%
10 2.74% 7.017%
15 5.042% 13.019%
20 8.77% 21.238%

Relationships between endpoints

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Index endpoint: I9_HYPOTE – Hypotension

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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