No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
427 |
4. Check minimum number of eventsNone |
427 |
5. Include endpointsNone |
427 |
6. Filter based on genotype QC (FinnGen only) |
410 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5
Similar endpoints
↥List of similar endpoints to
Hypotension due to drugs
based on the number of shared cases.
Similar with more cases:
- Hypotension
- Other CVD (FINNGEN)
- Other CVD
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4146 | 2120 | 2001 |
| Only index persons | 3614 | 1853 | 1761 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.06 | 0.06 |
| Only index persons | 0.07 | 0.07 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 77.94 | 80.37 | 75.41 |
| Only index persons | 77.93 | 80.44 | 75.30 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 410 | 165 | 245 |
| Unadjusted period prevalence (%) | 0.10 | 0.06 | 0.12 |
| Median age at first event (years) | 73.41 | 73.12 | 73.61 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint HYPOTE_DRUGS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| HYPOTE_DRUGS | 2.009 [1.68, 2.4] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.442 |
During the follow-up period (1.1.1998 — 31.12.2019), 1003 out of 1827 females with HYPOTE_DRUGS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| HYPOTE_DRUGS | 2.434 [1.91, 3.11] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 948 out of 1685 males with HYPOTE_DRUGS died.
Mortality risk
Mortality risk for people of age
years, who have HYPOTE_DRUGS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.193% | 0.515% |
| 5 | 1.172% | 2.872% |
| 10 | 2.94% | 6.92% |
| 15 | 5.423% | 12.823% |
| 20 | 9.768% | 21.299% |
Relationships between endpoints
↥Index endpoint: HYPOTE_DRUGS – Hypotension due to drugs
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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