≡ Risteys
FG R11 + FR

Documentation Changelog GitHub Contact & Feedback

Other arterial embolism and thrombosis

EFO MESH Endpoint Browser PheWeb

I9_ARTEMBTHRNAS

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I74
  • Hospital discharge: ICD-9 — 444
  • Hospital discharge: ICD-8 — 444
  • Hospital discharge: excluded ICD-10 — I74.0, I74.3
  • Hospital discharge: excluded ICD-9 — 4440A|4442A
  • Hospital discharge: excluded ICD-8 — 4440
  • Cause of death: ICD-10 — I74
  • Cause of death: ICD-9 — 444
  • Cause of death: ICD-8 — 444
  • Cause of death: excluded ICD-10 — I74.0, I74.3
  • Cause of death: excluded ICD-9 — 4440A|4442A
  • Cause of death: excluded ICD-8 — 4440

2 out of 7 registries used, show all original rules.

978

4. Check minimum number of events

None

978

5. Include endpoints

None

978

6. Filter based on genotype QC (FinnGen only)

946

Control definitions (FinnGen only)

Control exclude I9_DOAAC

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I70-I79
Name in latin Embolia/thrombosis arterialis

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 12491 5570 6660
Only index persons 6806 3245 3561
Unadjusted period prevalence (%)
Whole population 0.18 0.16 0.19
Only index persons 0.13 0.12 0.14
Median age at first event (years)
Whole population 69.83 73.96 66.55
Only index persons 69.06 72.68 65.76

-FinnGen-

Key figures

All Female Male
Number of individuals 946 333 613
Unadjusted period prevalence (%) 0.25 0.13 0.31
Median age at first event (years) 65.80 62.27 67.71

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

↥

Association

Association between endpoint I9_ARTEMBTHRNAS and mortality.

Females

Parameter HR [95% CI] p-value
I9_ARTEMBTHRNAS 2.389 [2.05, 2.78] < 0.001
Birth year 0.993 [0.98, 1.0] 0.114

During the follow-up period (1.1.1998 — 31.12.2019), 1666 out of 2840 females with I9_ARTEMBTHRNAS died.

Males

Parameter HR [95% CI] p-value
I9_ARTEMBTHRNAS 2.449 [2.11, 2.84] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 1723 out of 3223 males with I9_ARTEMBTHRNAS died.

Mortality risk

Mortality risk for people of age

years, who have I9_ARTEMBTHRNAS.

N-year risk Females Males
1 0.209% 0.413%
5 1.364% 2.466%
10 3.181% 6.348%
15 6.186% 11.908%
20 11.086% 19.909%

Relationships between endpoints

↥

Index endpoint: I9_ARTEMBTHRNAS – Other arterial embolism and thrombosis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data