eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
118 |
4. Check minimum number of eventsNone |
118 |
5. Include endpointsNone |
118 |
6. Filter based on genotype QC (FinnGen only) |
110 |
Control definitions (FinnGen only)
Control exclude
H8_OTHEREAR
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H95
Name in latin
Aliae morbositates post operationem auris mediae
Similar endpoints
↥List of similar endpoints to
Other disorders following mastoidectomy
based on the number of shared cases.
Similar with more cases:
- Postprocedural disorders of ear and mastoid process, not elsewhere classified
- Other disorders of ear
- Diseases of the ear and mastoid process
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1322 | 658 | 658 |
| Only index persons | 1256 | 626 | 630 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 65.04 | 68.12 | 61.92 |
| Only index persons | 64.61 | 67.69 | 61.56 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 110 | 52 | 58 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | 62.39 | 61.37 | 63.30 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint H8_POSTMASTNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_POSTMASTNAS | 1.322 [1.09, 1.61] | 0.006 |
| Birth year | 0.994 [0.99, 1.0] | 0.194 |
During the follow-up period (1.1.1998 — 31.12.2019), 152 out of 602 females with H8_POSTMASTNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_POSTMASTNAS | 1.037 [0.84, 1.29] | 0.741 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 142 out of 605 males with H8_POSTMASTNAS died.
Mortality risk
Mortality risk for people of age
years, who have H8_POSTMASTNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.151% | 0.198% |
| 5 | 0.789% | 1.264% |
| 10 | 1.944% | 2.977% |
| 15 | 3.714% | 5.379% |
| 20 | 6.312% | 9.286% |
Relationships between endpoints
↥Index endpoint: H8_POSTMASTNAS – Other disorders following mastoidectomy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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