Recurrent cholesteatoma of postmastoidectomy cavity

H8_POSTMASTCHOLEASTOMA

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H95.0
  • Cause of death: ICD-10 H95.0

2 out of 7 registries used, show all original rules.

104

4. Check minimum number of events

None

104

5. Include endpoints

None

104

6. Filter based on genotype QC (FinnGen only)

100

Control definitions (FinnGen only)

Control exclude H8_OTHEREAR

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H95
Name in latin Cholesteatoma postoperativum recidivum auris mediae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1043 467 574
Only index persons 986 440 546
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.02
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 55.47 58.07 53.39
Only index persons 54.74 57.43 52.57

-FinnGen-

Key figures

All Female Male
Number of individuals 100 42 58
Unadjusted period prevalence (%) 0.02 0.02 0.03
Median age at first event (years) 57.60 56.98 58.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint H8_POSTMASTCHOLEASTOMA and mortality.

Females

Parameter HR [95% CI] p-value
H8_POSTMASTCHOLEASTOMA 0.987 [0.78, 1.24] 0.91
Birth year 0.991 [0.98, 1.0] 0.042

During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 423 females with H8_POSTMASTCHOLEASTOMA died.

Males

Parameter HR [95% CI] p-value
H8_POSTMASTCHOLEASTOMA 1.045 [0.85, 1.29] 0.679
Birth year 0.985 [0.98, 0.99] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 109 out of 516 males with H8_POSTMASTCHOLEASTOMA died.

Mortality risk

Mortality risk for people of age

years, who have H8_POSTMASTCHOLEASTOMA.

N-year risk Females Males
1 0.117% 0.199%
5 0.516% 1.236%
10 1.229% 2.987%
15 2.24% 5.244%
20 3.872% 9.083%

Relationships between endpoints

Index endpoint: H8_POSTMASTCHOLEASTOMA – Recurrent cholesteatoma of postmastoidectomy cavity

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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