paralytic strabismus: An ocular deviation caused by a palsy to one or more of the extraocular muscles or nerves supplying them. [database_cross_reference: ORCID:0000-0003-0986-4123][database_cross_reference: ORCID:0000-0003-0986-4123]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
2293 |
4. Check minimum number of eventsNone |
2293 |
5. Include endpoints |
2427 |
6. Filter based on genotype QC (FinnGen only) |
2326 |
Control definitions (FinnGen only)
Control exclude
H7_OCUMUSCLE
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H49-H52
Name in latin
Strabismus paralyticus
Similar endpoints
↥List of similar endpoints to
Paralytic strabismus
based on the number of shared cases.
Similar with more cases:
- Strabismus
- Disorders of ocular muscles, binocular movement, accommodation and refraction
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 18942 | 9349 | 9495 |
| Only index persons | 16522 | 8232 | 8290 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.27 | 0.27 | 0.27 |
| Only index persons | 0.31 | 0.30 | 0.32 |
| Median age at first event (years) | |||
| Whole population | 61.07 | 61.75 | 60.34 |
| Only index persons | 60.55 | 61.10 | 60.01 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2326 | 1169 | 1157 |
| Unadjusted period prevalence (%) | 0.52 | 0.46 | 0.58 |
| Median age at first event (years) | 60.38 | 57.27 | 63.53 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_PARASTRAB and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PARASTRAB | 1.349 [1.22, 1.49] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.034 |
During the follow-up period (1.1.1998 — 31.12.2019), 1840 out of 7311 females with H7_PARASTRAB died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PARASTRAB | 1.428 [1.29, 1.58] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 2050 out of 7503 males with H7_PARASTRAB died.
Mortality risk
Mortality risk for people of age
years, who have H7_PARASTRAB.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.105% | 0.282% |
| 5 | 0.75% | 1.616% |
| 10 | 1.723% | 4.105% |
| 15 | 3.265% | 8.143% |
| 20 | 5.54% | 13.415% |
Relationships between endpoints
↥Index endpoint: H7_PARASTRAB – Paralytic strabismus
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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