No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
722 |
4. Check minimum number of eventsNone |
722 |
5. Include endpointsNone |
722 |
6. Filter based on genotype QC (FinnGen only) |
698 |
Control definitions (FinnGen only)
Control exclude
H7_OCUMUSCLE
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H49
Name in latin
Paresis/paralysis nervi trochlearis
Similar endpoints
↥List of similar endpoints to
Fourth [trochlear] nerve palsy
based on the number of shared cases.
Similar with more cases:
- Paralytic strabismus
- Strabismus
- Disorders of ocular muscles, binocular movement, accommodation and refraction
- Diseases of the eye and adnexa
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4786 | 2139 | 2632 |
| Only index persons | 4492 | 2022 | 2470 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.06 | 0.07 |
| Only index persons | 0.09 | 0.07 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 57.12 | 55.81 | 58.14 |
| Only index persons | 57.65 | 56.67 | 58.46 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 698 | 359 | 339 |
| Unadjusted period prevalence (%) | 0.16 | 0.14 | 0.17 |
| Median age at first event (years) | 59.16 | 55.25 | 63.31 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_PARASTRA4 and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PARASTRA4 | 1.027 [0.87, 1.22] | 0.763 |
| Birth year | 0.993 [0.98, 1.0] | 0.094 |
During the follow-up period (1.1.1998 — 31.12.2019), 244 out of 1915 females with H7_PARASTRA4 died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PARASTRA4 | 1.067 [0.92, 1.24] | 0.381 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 423 out of 2325 males with H7_PARASTRA4 died.
Mortality risk
Mortality risk for people of age
years, who have H7_PARASTRA4.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.062% | 0.187% |
| 5 | 0.54% | 1.149% |
| 10 | 1.428% | 2.73% |
| 15 | 2.727% | 5.162% |
| 20 | 4.625% | 8.737% |
Relationships between endpoints
↥Index endpoint: H7_PARASTRA4 – Fourth [trochlear] nerve palsy
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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