No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
571 |
4. Check minimum number of eventsNone |
571 |
5. Include endpointsNone |
571 |
6. Filter based on genotype QC (FinnGen only) |
551 |
Control definitions (FinnGen only)
Control exclude
H7_OCUMUSCLE
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H49
Name in latin
Paresis/paralysis nervi oculomotorii
Similar endpoints
↥List of similar endpoints to
Third [oculomotor] nerve palsy
based on the number of shared cases.
Similar with more cases:
- Paralytic strabismus
- Strabismus
- Disorders of ocular muscles, binocular movement, accommodation and refraction
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4483 | 2283 | 2171 |
| Only index persons | 3953 | 2021 | 1932 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.07 | 0.06 |
| Only index persons | 0.07 | 0.07 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 65.73 | 66.58 | 64.73 |
| Only index persons | 64.72 | 65.45 | 63.95 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 551 | 289 | 262 |
| Unadjusted period prevalence (%) | 0.12 | 0.11 | 0.13 |
| Median age at first event (years) | 62.07 | 58.53 | 65.98 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_PARASTRA3 and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PARASTRA3 | 1.566 [1.37, 1.79] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.183 |
During the follow-up period (1.1.1998 — 31.12.2019), 692 out of 1999 females with H7_PARASTRA3 died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PARASTRA3 | 1.569 [1.36, 1.81] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.022 |
During the follow-up period (1.1.1998 — 31.12.2019), 689 out of 1924 males with H7_PARASTRA3 died.
Mortality risk
Mortality risk for people of age
years, who have H7_PARASTRA3.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.185% | 0.384% |
| 5 | 0.985% | 1.951% |
| 10 | 2.446% | 4.668% |
| 15 | 4.765% | 8.998% |
| 20 | 8.383% | 15.595% |
Relationships between endpoints
↥Index endpoint: H7_PARASTRA3 – Third [oculomotor] nerve palsy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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