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Other and unspecified iridocyclitis

DOID EFO Endpoint Browser PheWeb

H7_IRIDONAS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H20.8, H20.9
  • Hospital discharge: ICD-9 — 360[8-9]
  • Hospital discharge: ICD-8 — 36409
  • Cause of death: ICD-10 — H20.8, H20.9
  • Cause of death: ICD-9 — 360[8-9]
  • Cause of death: ICD-8 — 36409

2 out of 7 registries used, show all original rules.

1426

4. Check minimum number of events

None

1426

5. Include endpoints

None

1426

6. Filter based on genotype QC (FinnGen only)

1365

Control definitions (FinnGen only)

Control exclude H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 11036 5749 5192
Only index persons 10269 5457 4812
Unadjusted period prevalence (%)
Whole population 0.15 0.16 0.15
Only index persons 0.19 0.20 0.18
Median age at first event (years)
Whole population 50.38 52.90 47.83
Only index persons 50.04 52.50 47.24

-FinnGen-

Key figures

All Female Male
Number of individuals 1365 786 579
Unadjusted period prevalence (%) 0.30 0.31 0.29
Median age at first event (years) 54.49 54.66 54.26

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint H7_IRIDONAS and mortality.

Females

Parameter HR [95% CI] p-value
H7_IRIDONAS 1.081 [0.89, 1.32] 0.44
Birth year 0.992 [0.98, 1.0] 0.058

During the follow-up period (1.1.1998 — 31.12.2019), 258 out of 3952 females with H7_IRIDONAS died.

Males

Parameter HR [95% CI] p-value
H7_IRIDONAS 1.076 [0.87, 1.33] 0.501
Birth year 0.991 [0.98, 1.0] 0.049

During the follow-up period (1.1.1998 — 31.12.2019), 246 out of 3459 males with H7_IRIDONAS died.

Mortality risk

Mortality risk for people of age

years, who have H7_IRIDONAS.

N-year risk Females Males
1 0.08% 0.195%
5 0.567% 1.42%
10 1.378% 3.419%
15 2.569% 6.479%
20 4.615% 11.324%

Relationships between endpoints

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Index endpoint: H7_IRIDONAS – Other and unspecified iridocyclitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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