Iridocyclitis in diseases classified elsewhere

H7_IRIDOCYCLITISINOTH

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H22[0-1]
  • Cause of death: ICD-10 H22[0-1]

2 out of 7 registries used, show all original rules.

585

4. Check minimum number of events

None

585

5. Include endpoints

None

585

6. Filter based on genotype QC (FinnGen only)

558

Control definitions (FinnGen only)

Control exclude H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3920 2066 1843
Only index persons 3697 1955 1742
Unadjusted period prevalence (%)
Whole population 0.06 0.06 0.05
Only index persons 0.07 0.07 0.07
Median age at first event (years)
Whole population 53.62 55.44 51.59
Only index persons 53.59 55.89 51.00

-FinnGen-

Key figures

All Female Male
Number of individuals 558 309 249
Unadjusted period prevalence (%) 0.12 0.12 0.13
Median age at first event (years) 54.03 52.05 56.48

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint H7_IRIDOCYCLITISINOTH and mortality.

Females

Parameter HR [95% CI] p-value
H7_IRIDOCYCLITISINOTH 1.095 [0.91, 1.31] 0.326
Birth year 0.994 [0.99, 1.0] 0.156

During the follow-up period (1.1.1998 — 31.12.2019), 252 out of 1718 females with H7_IRIDOCYCLITISINOTH died.

Males

Parameter HR [95% CI] p-value
H7_IRIDOCYCLITISINOTH 1.374 [1.14, 1.66] 0.001
Birth year 0.985 [0.98, 0.99] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 266 out of 1621 males with H7_IRIDOCYCLITISINOTH died.

Mortality risk

Mortality risk for people of age

years, who have H7_IRIDOCYCLITISINOTH.

N-year risk Females Males
1 0.099% 0.265%
5 0.543% 1.506%
10 1.49% 3.577%
15 2.793% 6.832%
20 5.292% 11.356%

Relationships between endpoints

Index endpoint: H7_IRIDOCYCLITISINOTH – Iridocyclitis in diseases classified elsewhere

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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