Choroidal detachment

H7_CHORDETACH

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H31.4
  • Hospital discharge: ICD-9 3637
  • Hospital discharge: ICD-8 3785
  • Cause of death: ICD-10 H31.4
  • Cause of death: ICD-9 3637
  • Cause of death: ICD-8 3785

2 out of 7 registries used, show all original rules.

80

4. Check minimum number of events

None

80

5. Include endpoints

None

80

6. Filter based on genotype QC (FinnGen only)

74

Control definitions (FinnGen only)

Control exclude H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H31
Name in latin Ablatio chorioideae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 799 431 358
Only index persons 630 346 284
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 73.78 76.13 70.93
Only index persons 73.34 76.49 69.51

-FinnGen-

Key figures

All Female Male
Number of individuals 74 29 45
Unadjusted period prevalence (%) 0.02 0.01 0.02
Median age at first event (years) 69.83 66.98 71.67

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint H7_CHORDETACH and mortality.

Females

Parameter HR [95% CI] p-value
H7_CHORDETACH 0.994 [0.82, 1.21] 0.953
Birth year 0.994 [0.99, 1.0] 0.199

During the follow-up period (1.1.1998 — 31.12.2019), 151 out of 331 females with H7_CHORDETACH died.

Males

Parameter HR [95% CI] p-value
H7_CHORDETACH 0.9 [0.7, 1.15] 0.399
Birth year 0.987 [0.98, 1.0] 0.01

During the follow-up period (1.1.1998 — 31.12.2019), 108 out of 260 males with H7_CHORDETACH died.

Mortality risk

Mortality risk for people of age

years, who have H7_CHORDETACH.

N-year risk Females Males
1 0.071% 0.169%
5 0.545% 0.93%
10 1.404% 2.5%
15 2.849% 5.043%
20 4.983% 8.75%

Relationships between endpoints

Index endpoint: H7_CHORDETACH – Choroidal detachment

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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