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Felty syndrome

DOID EFO Endpoint Browser PheWeb

FELTY

Felty's syndrome: Felty syndrome (FS), also known as ''super rheumatoid'' disease, is a severe form of rheumatoid arthritis (RA), characterized by a triad of RA, splenomegaly and neutropenia, resulting in susceptibility to bacterial infections.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M05.0
  • Hospital discharge: ICD-9 — 7141
  • Hospital discharge: ICD-8 — 71210
  • Cause of death: ICD-10 — M05.0
  • Cause of death: ICD-9 — 7141
  • Cause of death: ICD-8 — 71210

2 out of 7 registries used, show all original rules.

174

4. Check minimum number of events

None

174

5. Include endpoints

None

174

6. Filter based on genotype QC (FinnGen only)

169

Control definitions (FinnGen only)

Control exclude RHEUMA_SEROPOS

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 M05
Name in latin Syndroma Felty

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2047 1446 568
Only index persons 1398 1042 356
Unadjusted period prevalence (%)
Whole population 0.03 0.04 0.02
Only index persons 0.03 0.04 0.01
Median age at first event (years)
Whole population 66.27 66.71 64.83
Only index persons 62.81 63.27 61.45

-FinnGen-

Key figures

All Female Male
Number of individuals 169 123 46
Unadjusted period prevalence (%) 0.04 0.05 0.02
Median age at first event (years) 59.27 58.47 61.42

-FinRegistry-

Age distribution of first events

0102030405060708090050100150200250300350400450500550AgeIndividuals

-FinnGen-

Age distribution of first events

01030405060708090051015202530354045AgeIndividuals

-FinRegistry-

Year distribution of first events

197019751980198519901995200020052010201520202022050100150200250300350400450500YearIndividuals

-FinnGen-

Year distribution of first events

19701975199520002005201020152020202305101520253035404550YearIndividuals

-FinRegistry-

Cumulative Incidence Function

01020304050607080901000.00.10.20.30.40.50.60.70.80.91.0AgeProbability of first incidence (%)

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint FELTY and mortality.

Females

Parameter HR [95% CI] p-value
FELTY 2.656 [2.3, 3.06] < 0.001
Birth year 0.998 [0.99, 1.01] 0.553

During the follow-up period (1.1.1998 — 31.12.2019), 536 out of 1102 females with FELTY died.

Males

Parameter HR [95% CI] p-value
FELTY 2.379 [1.86, 3.04] < 0.001
Birth year 0.984 [0.97, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 235 out of 414 males with FELTY died.

Mortality risk

Mortality risk for people of age

years, who have FELTY.

N-year risk Females Males
1 0.245% 0.413%
5 1.675% 2.536%
10 4.164% 6.464%
15 7.829% 11.817%
20 13.78% 19.08%

Relationships between endpoints

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Index endpoint: FELTY – Felty syndrome

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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