Felty's syndrome: Felty syndrome (FS), also known as ''super rheumatoid'' disease, is a severe form of rheumatoid arthritis (RA), characterized by a triad of RA, splenomegaly and neutropenia, resulting in susceptibility to bacterial infections.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
174 |
4. Check minimum number of eventsNone |
174 |
5. Include endpointsNone |
174 |
6. Filter based on genotype QC (FinnGen only) |
169 |
Control definitions (FinnGen only)
Control exclude
RHEUMA_SEROPOS
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M05
Name in latin
Syndroma Felty
Similar endpoints
↥List of similar endpoints to
Felty syndrome
based on the number of shared cases.
Similar with more cases:
- Seropositive rheumatoid arthritis
- Polyarthropathies
- Finngen Rheumatological endpoints
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2047 | 1446 | 568 |
| Only index persons | 1398 | 1042 | 356 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.02 |
| Only index persons | 0.03 | 0.04 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 66.27 | 66.71 | 64.83 |
| Only index persons | 62.81 | 63.27 | 61.45 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 169 | 123 | 46 |
| Unadjusted period prevalence (%) | 0.04 | 0.05 | 0.02 |
| Median age at first event (years) | 59.27 | 58.47 | 61.42 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint FELTY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| FELTY | 2.656 [2.3, 3.06] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.553 |
During the follow-up period (1.1.1998 — 31.12.2019), 536 out of 1102 females with FELTY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| FELTY | 2.379 [1.86, 3.04] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 235 out of 414 males with FELTY died.
Mortality risk
Mortality risk for people of age
years, who have FELTY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.245% | 0.413% |
| 5 | 1.675% | 2.536% |
| 10 | 4.164% | 6.464% |
| 15 | 7.829% | 11.817% |
| 20 | 13.78% | 19.08% |
Relationships between endpoints
↥Index endpoint: FELTY – Felty syndrome
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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