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Other reaction to severe stress, and adjustment disorders

EFO MESH Endpoint Browser PheWeb

F5_STRESSOTH

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F43
  • Hospital discharge: ICD-9 — 309
  • Hospital discharge: excluded ICD-10 — F43.1
  • Cause of death: ICD-10 — F43
  • Cause of death: ICD-9 — 309
  • Cause of death: excluded ICD-10 — F43.1

2 out of 7 registries used, show all original rules.

17747

4. Check minimum number of events

None

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5. Include endpoints

None

17747

6. Filter based on genotype QC (FinnGen only)

16901

Control definitions (FinnGen only)

Control exclude F5_NEUROTIC

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F40-F48
Name in latin Reactio e stressu severi

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 161189 94365 65650
Only index persons 149791 89662 60129
Unadjusted period prevalence (%)
Whole population 2.34 2.70 1.83
Only index persons 2.89 3.30 2.30
Median age at first event (years)
Whole population 33.89 37.12 29.19
Only index persons 33.12 36.43 28.17

-FinnGen-

Key figures

All Female Male
Number of individuals 16901 11778 5123
Unadjusted period prevalence (%) 4.00 4.63 2.57
Median age at first event (years) 39.53 39.73 39.07

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint F5_STRESSOTH and mortality.

Females

Parameter HR [95% CI] p-value
F5_STRESSOTH 2.553 [2.31, 2.82] < 0.001
Birth year 0.993 [0.99, 1.0] 0.085

During the follow-up period (1.1.1998 — 31.12.2019), 8066 out of 79498 females with F5_STRESSOTH died.

Males

Parameter HR [95% CI] p-value
F5_STRESSOTH 2.703 [2.46, 2.97] < 0.001
Birth year 0.984 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 6416 out of 46788 males with F5_STRESSOTH died.

Mortality risk

Mortality risk for people of age

years, who have F5_STRESSOTH.

N-year risk Females Males
1 0.25% 0.367%
5 1.428% 2.63%
10 3.233% 6.752%
15 6.242% 12.629%
20 10.994% 20.532%

Relationships between endpoints

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Index endpoint: F5_STRESSOTH – Other reaction to severe stress, and adjustment disorders

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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