Other reaction to severe stress, and adjustment disorders

F5_STRESSOTH

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 F43
  • Hospital discharge: ICD-9 309
  • Hospital discharge: excluded ICD-10 F43.1
  • Cause of death: ICD-10 F43
  • Cause of death: ICD-9 309
  • Cause of death: excluded ICD-10 F43.1

2 out of 7 registries used, show all original rules.

17747

4. Check minimum number of events

None

17747

5. Include endpoints

None

17747

6. Filter based on genotype QC (FinnGen only)

16901

Control definitions (FinnGen only)

Control exclude F5_NEUROTIC

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F40-F48
Name in latin Reactio e stressu severi

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 161189 94365 65650
Only index persons 149791 89662 60129
Unadjusted period prevalence (%)
Whole population 2.34 2.70 1.83
Only index persons 2.89 3.30 2.30
Median age at first event (years)
Whole population 33.89 37.12 29.19
Only index persons 33.12 36.43 28.17

-FinnGen-

Key figures

All Female Male
Number of individuals 16901 11778 5123
Unadjusted period prevalence (%) 4.00 4.63 2.57
Median age at first event (years) 39.53 39.73 39.07

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint F5_STRESSOTH and mortality.

Females

Parameter HR [95% CI] p-value
F5_STRESSOTH 2.553 [2.31, 2.82] < 0.001
Birth year 0.993 [0.99, 1.0] 0.085

During the follow-up period (1.1.1998 — 31.12.2019), 8066 out of 79498 females with F5_STRESSOTH died.

Males

Parameter HR [95% CI] p-value
F5_STRESSOTH 2.703 [2.46, 2.97] < 0.001
Birth year 0.984 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 6416 out of 46788 males with F5_STRESSOTH died.

Mortality risk

Mortality risk for people of age

years, who have F5_STRESSOTH.

N-year risk Females Males
1 0.25% 0.367%
5 1.428% 2.63%
10 3.233% 6.752%
15 6.242% 12.629%
20 10.994% 20.532%

Relationships between endpoints

Index endpoint: F5_STRESSOTH – Other reaction to severe stress, and adjustment disorders

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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