somatoform disorder: A category of psychiatric disorders which are characterized by the presence of physical symptoms that suggest a medical condition but are not fully explained by any known medical reasons. [database_cross_reference: NCIT:C34956]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
6664 |
4. Check minimum number of eventsNone |
6664 |
5. Include endpointsNone |
6664 |
6. Filter based on genotype QC (FinnGen only) |
6392 |
Control definitions (FinnGen only)
Control exclude
F5_NEUROTIC
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F40-F48
Name in latin
Perturbationes somatoformes
Similar endpoints
↥List of similar endpoints to
Somatoform disorder
based on the number of shared cases.
Similar with more cases:
- Neurotic, stress-related and somatoform disorders
- Anxiety disorders
- Anxiety disorders
- Any mental disorder
- Psychiatric diseases
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 50413 | 32373 | 17694 |
| Only index persons | 46475 | 30344 | 16131 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.77 | 0.93 | 0.49 |
| Only index persons | 0.94 | 1.12 | 0.62 |
| Median age at first event (years) | |||
| Whole population | 44.83 | 46.21 | 42.32 |
| Only index persons | 44.11 | 45.46 | 41.56 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 6392 | 4542 | 1850 |
| Unadjusted period prevalence (%) | 1.54 | 1.78 | 0.93 |
| Median age at first event (years) | 46.12 | 45.91 | 46.66 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint F5_SOMATOFORM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_SOMATOFORM | 1.294 [1.17, 1.43] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.045 |
During the follow-up period (1.1.1998 — 31.12.2019), 2265 out of 23873 females with F5_SOMATOFORM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_SOMATOFORM | 1.275 [1.15, 1.42] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 1449 out of 12088 males with F5_SOMATOFORM died.
Mortality risk
Mortality risk for people of age
years, who have F5_SOMATOFORM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.128% | 0.309% |
| 5 | 0.621% | 1.541% |
| 10 | 1.678% | 3.665% |
| 15 | 3.135% | 7.101% |
| 20 | 5.464% | 11.834% |
Relationships between endpoints
↥Index endpoint: F5_SOMATOFORM – Somatoform disorder
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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