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Disorder of the sleep-wake schedule

EFO Endpoint Browser PheWeb

F5_SLEEPWAKE

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F51.2, G47.2
  • Hospital discharge: ICD-9 — 3074F
  • Cause of death: ICD-10 — F51.2, G47.2
  • Cause of death: ICD-9 — 3074F

2 out of 7 registries used, show all original rules.

580

4. Check minimum number of events

None

580

5. Include endpoints

None

580

6. Filter based on genotype QC (FinnGen only)

548

Control definitions (FinnGen only)

Control exclude F5_SLEEP

Extra metadata

First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6901 3035 3847
Only index persons 5380 2449 2931
Unadjusted period prevalence (%)
Whole population 0.10 0.09 0.11
Only index persons 0.10 0.09 0.11
Median age at first event (years)
Whole population 17.72 18.07 17.36
Only index persons 23.48 23.54 23.43

-FinnGen-

Key figures

All Female Male
Number of individuals 548 294 254
Unadjusted period prevalence (%) 0.12 0.12 0.13
Median age at first event (years) 42.10 38.27 46.53

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint F5_SLEEPWAKE and mortality.

Females

Parameter HR [95% CI] p-value
F5_SLEEPWAKE 2.192 [1.67, 2.88] < 0.001
Birth year 0.99 [0.98, 1.0] 0.03

During the follow-up period (1.1.1998 — 31.12.2019), 157 out of 2225 females with F5_SLEEPWAKE died.

Males

Parameter HR [95% CI] p-value
F5_SLEEPWAKE 2.046 [1.64, 2.55] < 0.001
Birth year 0.988 [0.98, 1.0] 0.011

During the follow-up period (1.1.1998 — 31.12.2019), 288 out of 2839 males with F5_SLEEPWAKE died.

Mortality risk

Mortality risk for people of age

years, who have F5_SLEEPWAKE.

N-year risk Females Males
1 0.236% 0.3%
5 1.1% 2.454%
10 2.53% 6.216%
15 4.99% 11.799%
20 8.937% 19.409%

Relationships between endpoints

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Index endpoint: F5_SLEEPWAKE – Disorder of the sleep-wake schedule

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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