sexual dysfunction: ['Disturbances in sexual desire and the psychophysiologic changes that characterize the sexual response cycle and cause marked distress and interpersonal difficulty.']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
479 |
4. Check minimum number of eventsNone |
479 |
5. Include endpointsNone |
479 |
6. Filter based on genotype QC (FinnGen only) |
459 |
Control definitions (FinnGen only)
Control exclude
F5_BEHAVE
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F50-F59
Name in latin
Perturbationes sexuales non organicae
Similar endpoints
↥List of similar endpoints to
Sexual dysfunction
based on the number of shared cases.
Similar with more cases:
- Behavioural syndromes associated with physiological disturbances and physical factors
- Any mental disorder
- Psychiatric diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3670 | 859 | 2778 |
| Only index persons | 3531 | 836 | 2695 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.02 | 0.08 |
| Only index persons | 0.09 | 0.03 | 0.10 |
| Median age at first event (years) | |||
| Whole population | 40.63 | 32.07 | 43.31 |
| Only index persons | 40.15 | 31.85 | 42.72 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 459 | 137 | 322 |
| Unadjusted period prevalence (%) | 0.13 | 0.05 | 0.16 |
| Median age at first event (years) | 46.09 | 36.59 | 50.13 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint F5_SEXDYS and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_SEXDYS | 1.439 [1.19, 1.75] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.026 |
During the follow-up period (1.1.1998 — 31.12.2019), 176 out of 1694 males with F5_SEXDYS died.
Mortality risk
Mortality risk for people of age
years, who have F5_SEXDYS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.287% |
| 5 | No data | 1.854% |
| 10 | No data | 4.492% |
| 15 | No data | 8.385% |
| 20 | No data | 14.164% |
Relationships between endpoints
↥Index endpoint: F5_SEXDYS – Sexual dysfunction
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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