post-traumatic stress disorder: An anxiety disorder precipitated by an experience of intense fear or horror while exposed to a traumatic (especially life-threatening) event. The disorder is characterized by intrusive recurring thoughts or images of the traumatic event; avoidance of anything associated with the event; a state of hyperarousal and diminished emotional responsiveness. These symptoms are present for at least one month and the disorder is usually long-term.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3263 |
4. Check minimum number of eventsNone |
3263 |
5. Include endpointsNone |
3263 |
6. Filter based on genotype QC (FinnGen only) |
3005 |
Control definitions (FinnGen only)
Control exclude
F5_NEUROTIC
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F43
Name in latin
Perturbatio stressualis posttraumatica
Similar endpoints
↥List of similar endpoints to
Post-traumatic stress disorder
based on the number of shared cases.
Similar with more cases:
- Neurotic, stress-related and somatoform disorders
- Anxiety disorders
- Anxiety disorders
- Any mental disorder
- Psychiatric diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 30821 | 21836 | 8585 |
| Only index persons | 29539 | 21436 | 8103 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.52 | 0.63 | 0.24 |
| Only index persons | 0.66 | 0.79 | 0.31 |
| Median age at first event (years) | |||
| Whole population | 28.54 | 27.97 | 29.72 |
| Only index persons | 28.40 | 27.93 | 29.67 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3005 | 2483 | 522 |
| Unadjusted period prevalence (%) | 0.85 | 0.98 | 0.26 |
| Median age at first event (years) | 34.94 | 33.55 | 41.58 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint F5_PTSD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_PTSD | 2.108 [1.82, 2.44] | < 0.001 |
| Birth year | 1.0 [0.99, 1.01] | 0.906 |
During the follow-up period (1.1.1998 — 31.12.2019), 591 out of 17205 females with F5_PTSD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_PTSD | 1.812 [1.57, 2.09] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.037 |
During the follow-up period (1.1.1998 — 31.12.2019), 503 out of 7041 males with F5_PTSD died.
Mortality risk
Mortality risk for people of age
years, who have F5_PTSD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.192% | 0.349% |
| 5 | 1.409% | 2.327% |
| 10 | 3.586% | 5.885% |
| 15 | 6.98% | 10.968% |
| 20 | 12.352% | 18.419% |
Relationships between endpoints
↥Index endpoint: F5_PTSD – Post-traumatic stress disorder
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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