Unspecified behavioural syndromes associated with physiological disturbances and physical factors +Physiological and behavioural factors associated with disorders of diseases classified elsewhere

F5_PHYSBEHOTH

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 F54
  • Hospital discharge: ICD-9 316
  • Cause of death: ICD-10 F54
  • Cause of death: ICD-9 316

2 out of 7 registries used, show all original rules.

576

4. Check minimum number of events

None

576

5. Include endpoints

None

576

6. Filter based on genotype QC (FinnGen only)

545

Control definitions (FinnGen only)

Control exclude F5_BEHAVE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Similar endpoints

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4724 2748 1950
Only index persons 4145 2451 1694
Unadjusted period prevalence (%)
Whole population 0.07 0.08 0.05
Only index persons 0.08 0.09 0.06
Median age at first event (years)
Whole population 29.95 34.14 23.70
Only index persons 28.04 32.65 21.36

-FinnGen-

Key figures

All Female Male
Number of individuals 545 352 193
Unadjusted period prevalence (%) 0.12 0.14 0.10
Median age at first event (years) 33.36 33.47 33.16

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint F5_PHYSBEHOTH and mortality.

Females

Parameter HR [95% CI] p-value
F5_PHYSBEHOTH 3.716 [3.0, 4.6] < 0.001
Birth year 0.991 [0.98, 1.0] 0.041

During the follow-up period (1.1.1998 — 31.12.2019), 316 out of 2207 females with F5_PHYSBEHOTH died.

Males

Parameter HR [95% CI] p-value
F5_PHYSBEHOTH 3.261 [2.58, 4.12] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 261 out of 1537 males with F5_PHYSBEHOTH died.

Mortality risk

Mortality risk for people of age

years, who have F5_PHYSBEHOTH.

N-year risk Females Males
1 0.399% 0.601%
5 1.878% 3.387%
10 4.839% 8.455%
15 9.05% 15.842%
20 15.128% 25.809%

Relationships between endpoints

Index endpoint: F5_PHYSBEHOTH – Unspecified behavioural syndromes associated with physiological disturbances and physical factors +Physiological and behavioural factors associated with disorders of diseases classified elsewhere

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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