neurotic disorder: A form of functional mental illness that manifests in distressed emotional reactions such as anxiety, obsessive thoughts, compulsive behaviors, or irrational fears.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1815 |
4. Check minimum number of eventsNone |
1815 |
5. Include endpointsNone |
1815 |
6. Filter based on genotype QC (FinnGen only) |
1744 |
Control definitions (FinnGen only)
Control exclude
F5_NEUROTIC
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F40-F48
Name in latin
Aliae perturbationes neuroticae
Similar endpoints
↥List of similar endpoints to
Other neurotic disorders
based on the number of shared cases.
Similar with more cases:
- Neurotic, stress-related and somatoform disorders
- Anxiety disorders
- Anxiety disorders
- Any mental disorder
- Psychiatric diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 23078 | 12208 | 10547 |
| Only index persons | 16788 | 9189 | 7599 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.32 | 0.35 | 0.29 |
| Only index persons | 0.32 | 0.34 | 0.29 |
| Median age at first event (years) | |||
| Whole population | 34.02 | 37.82 | 29.23 |
| Only index persons | 30.41 | 34.08 | 25.97 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1744 | 937 | 807 |
| Unadjusted period prevalence (%) | 0.39 | 0.37 | 0.41 |
| Median age at first event (years) | 29.45 | 31.00 | 27.65 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint F5_NEUROTICOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_NEUROTICOTH | 1.612 [1.39, 1.87] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.028 |
During the follow-up period (1.1.1998 — 31.12.2019), 537 out of 2534 females with F5_NEUROTICOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_NEUROTICOTH | 1.789 [1.5, 2.14] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.037 |
During the follow-up period (1.1.1998 — 31.12.2019), 364 out of 1494 males with F5_NEUROTICOTH died.
Mortality risk
Mortality risk for people of age
years, who have F5_NEUROTICOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.119% | 0.413% |
| 5 | 0.873% | 2.25% |
| 10 | 2.083% | 5.538% |
| 15 | 3.789% | 10.562% |
| 20 | 6.669% | 17.829% |
Relationships between endpoints
↥Index endpoint: F5_NEUROTICOTH – Other neurotic disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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